N,N-二甲基十四烷酰胺 | 3015-65-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N,N-二甲基十四烷酰胺
• 英文名称: N,N-dimethyltetradecanamide
• 英文别名: N,N-dimethylmyristamide；N,N-dimethyl-myristamide；N,N-Dimethyl-myristamid；Myristinsaeure-dimethylamid；N.N-Dimethyl-myristinamid；N,N-dimethyl tetradecanamide
• CAS: 3015-65-4
• 化学式: C₁₆H₃₃NO
• 分子量: 255.444
• InChiKey: FQXSTGKJHBFSIQ-UHFFFAOYSA-N

物化性质

• 熔点：
  29 °C
• 沸点：
  398.67°C (rough estimate)
• 密度：
  0.8876 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2924199090

SDS

Version 1.2
Regulation (EC) No 1907/2006

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1 - Product and Company Information

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Product Name N,N-DIMETHYLTETRADECANAMIDE

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2 - Hazards Identification

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3 - Composition/Information on Ingredients

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Product Name CAS # EC no Annex I
Index Number
MYRISTIC ACID, 3015-65-4 221-151-0 None
N,N-DIMETHYLAMIDEAPPROX. 98%
Formula C16H33NO
Molecular Weight 255,4300 AMU
Synonyms N,N-Dimethylmyristamide *
N,N-Dimethyltetradecanamide

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4 - First Aid Measures

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AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

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5 - Fire Fighting Measures

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EXTINGUISHING MEDIA
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Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

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6 - Accidental Release Measures

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PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.

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7 - Handling and Storage

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HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.

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8 - Exposure Controls / Personal Protection

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ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Respiratory protection is not required. Where
protection is desired, use multi-purpose combination (US) or type
ABEK (EN 14387) respirator cartridges.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.

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9 - Physical and Chemical Properties

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pH N/A
BP/BP Range 164,000. - 183,000 °3,000 mmHg
C.
MP/MP Range 26,000. - 27,000 °C.
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
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Vapor Pressure N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

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10 - Stability and Reactivity

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STABILITY
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.

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11 - Toxicological Information

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RTECS NUMBER: XB7950000
ACUTE TOXICITY
LD50
Intraperitoneal
Mouse
1430 MG/KG
Remarks: Behavioral:Change in motor activity (specific assay).
Lungs, Thorax, or Respiration:Dyspnea. Blood: Hemorrhage.
LD50
Intravenous
Mouse
150 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Somnolence (general depressed activity).
LD50
Intraperitoneal
Rabbit
1500 MG/KG
Remarks: Behavioral:Change in motor activity (specific assay).
Lungs, Thorax, or Respiration:Dyspnea. Blood: Hemorrhage.
LD50
Intravenous
Rabbit
84 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
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toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Eye Contact: May cause eye irritation.
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption.

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.

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14 - Transport Information

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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

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15 - Regulatory Information

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COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH www.molbase.com

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为产物：
  描述：

  1-十三烯 、 N,N-二甲基甲酰胺 在 bis(1,5-cyclooctadiene)nickel (0) 、 三乙基铝 、 IAd 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以84%的产率得到N,N-二甲基十四烷酰胺
  参考文献：
  名称：

  1-烯烃的区域选择性烃甲酰化

  摘要：

  源自 [Ni(cod)2]、AlEt3 和 N-杂环卡宾 (NHC) 的镍/路易斯酸协同催化作用可对 1-烯烃进行高度区域选择性的烃甲酰化。各种替代形式...

  DOI：

  10.1246/cl.2012.298

文献信息

• PROCESS FOR PRODUCING NITROGEN-CONTAINING COMPOUNDS
  申请人：Terasaka Michio

  公开号：US20100179349A1

  公开（公告）日：2010-07-15

  The present invention relates to a process for producing a tertiary amine by reducing an amide compound in the presence of a catalyst containing a sponge copper catalyst obtained by leaching alloy particles containing copper and aluminum and drying the thus leached alloy particles. The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products at a high yield by subjecting aliphatic acid amides to hydrogenation reduction under solvent-free moderate conditions.

  本发明涉及一种在存在含有海绵铜催化剂的催化剂的情况下，通过还原酰胺化合物来生产三级胺的方法，所述海绵铜催化剂是通过浸出含有铜和铝的合金颗粒并干燥浸出的合金颗粒获得的。本发明提供了一种在无溶剂适度条件下将脂肪酸酰胺经过加氢还原处理以高产率产生含有少量副产物的高纯度脂肪族三级胺的方法。
• [EN] PROCESS FOR PRODUCING NITROGEN-CONTAINING COMPOUNDS<br/>[FR] PROCÉDÉ DE PRODUCTION DE COMPOSÉS AZOTÉS
  申请人：KAO CORP

  公开号：WO2009020244A1

  公开（公告）日：2009-02-12

  The present invention relates to a process for producing a tertiary amine in the presence of a catalyst containing copper and at least one element selected from the group consisting of elements belonging to Groups 2, 3, 7 and 12 of the Periodic Table (long form of the periodic table), said process including the steps of (a) reducing an amide compound in a hydrogen atmosphere; and (b) introducing a dialkyl amine containing a linear or branched alkyl group having 1 to 6 carbon atoms into a reaction product obtained in the step (a), and treating the reaction product with the dialkyl amine. The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products by reducing aliphatic acid amides under moderate conditions using a chromium-free catalyst, as well as a process for producing amine derivatives such as amine oxide by using the aliphatic tertiary amines, with a good productivity in an economical manner.

  本发明涉及一种在含有铜和周期表长形式中属于2、3、7和12族元素之一的至少一种元素的催化剂存在下生产三级胺的方法，该方法包括以下步骤：(a) 在氢气氛中还原酰胺化合物；和(b) 将含有1至6个碳原子的线性或支链烷基基团的二烷基胺引入在步骤(a)中获得的反应产物中，并用二烷基胺处理反应产物。本发明提供了一种在中等条件下使用无铬催化剂还原脂肪酸酰胺从而生产含有较少副产物的高纯度脂肪族三级胺的方法，以及一种通过使用脂肪族三级胺生产胺氧化物等胺衍生物的方法，具有良好的经济生产能力。
• 脂肪族羧酸酰胺的制备方法
  申请人：丰益高分子材料（连云港）有限公司

  公开号：CN103833569B

  公开（公告）日：2016-12-21

  本发明涉及一种脂肪族羧酸酰胺的制备方法，所述方法包括使脂肪族羧酸与含有具有1‑4个碳原子的单烷基胺或二烷基胺在二氧化铈存在下反应。利用该方法可以高收率的制备脂肪族羧酸酰胺，并且催化剂显示出优异的催化效率和重复使用稳定性。
• NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS
  申请人：DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL

  公开号：US20150111935A1

  公开（公告）日：2015-04-23

  The present invention relates to a novel class of 1,3-benzoxazol-2(3H)-ones and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的1,3-苯并噁唑-2(3H)-酮类化合物及其作为药物的用途，尤其是作为皮肤科药剂和化妆品的用途。这些新型化合物在治疗和/或预防患者的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏症状方面特别有用。通常它们以药用或化妆品组合物的形式局部应用于皮肤或黏膜，包括该化合物和一种药学和/或化妆学可接受的载体。
• Lösungsmittel für Phasentransferkatalysierte Reaktionen
  申请人：Cognis IP Management GmbH

  公开号：EP1953127A2

  公开（公告）日：2008-08-06

  Organischen Substanzen mit einem log P - Wert von mehr als 2,6 (wobei der log P-Wert experimentell gemäß der "OECD Guideline No. 107 for the testing of chemicals" vom 27.07.95 bestimmt wird) eignen sich als Lösungsmittel für Reaktionen, die durch Phasentransfer-Katalysatoren beschleunigt werden.

  对数 P 值大于 2.6 的有机物质（对数 P 值根据 1995 年 7 月 27 日 "经合组织第 107 号化学品测试准则 "通过实验确定）适合用作相转移催化剂加速反应的溶剂。