1,3,5-Triphenyltetrazol-1-ium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3,5-Triphenyltetrazol-1-ium
• 化学式: C19H15N4+
• 分子量: 299.3
• InChiKey: AVPDSNGVGADFAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Methods and compositions for the visualization of cellular organelles using tetrazolium salts
  申请人：——

  公开号：US20020086345A1

  公开（公告）日：2002-07-04

  The invention provides a biochemical method for visualizing cellular organelles (such as centrosome) and/or cytoskeletons (such as microtubules) through the use of crystallizing agents (such as tetrazolium salts), a kit containing crystallizing agents adapted for such uses, and to methods particularly for detecting neoplastic cells in a tissue sample, suspension, or a fluid sample by examining the cells for abnormalities of cellular organelles (such as centrosome) and/or cytoskeletons (such as microtubules) in the number and shapes.

  本发明提供了一种通过使用结晶剂（如四唑盐）观察细胞器（如中心体）和/或细胞骨架（如微管）的生化方法，一种含有适用于这种用途的结晶剂的试剂盒、以及通过检查细胞中细胞器（如中心体）和/或细胞骨架（如微管）的数量和形状是否异常来检测组织样品、悬浮液或液体样品中肿瘤细胞的方法。
• Method and composition for treating cancer using cellular organelle crystallizing agents
  申请人：——

  公开号：US20020143042A1

  公开（公告）日：2002-10-03

  This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular organelle and/or cytoskeleton crystallizing agents (e.g. tetrazolium salts and their derivatives), pharmaceutical compositions containing a therapeutically effective amount of organelle and/or cytoskeleton crystallizing agents, and compositions containing organelle and/or cytoskeleton crystallizing agents in combination With a pharmaceutically acceptable carrier, diluent or excipient. The crystallizing agents with or without a pharmaceutically acceptable carrier, diluent or excipient, are used in combination with surgery and/or non-surgical anti-tumor treatments.

  本发明提供了一种通过细胞器-结晶-诱导死亡（此处定义为 "Cocid"）治疗哺乳动物癌症的方法，一种使用细胞器和/或细胞骨架结晶剂（如四唑盐及其衍生物）治疗癌症的方法，一种含有治疗有效量的细胞器和/或细胞骨架结晶剂的药物组合物，以及含有细胞器和/或细胞骨架结晶剂的组合物。四唑盐及其衍生物）、含有治疗有效量的细胞器和/或细胞骨架结晶剂的药物组合物，以及含有细胞器和/或细胞骨架结晶剂与药学上可接受的载体、稀释剂或赋形剂的组合物。结晶剂与或不与药学上可接受的载体、稀释剂或赋形剂结合，可用于手术和/或非手术抗肿瘤治疗。
• METHOD FOR TREATING CANCER, VISUALIZING CELL STRUCTURES, AND ISOLATING ORGANELLES USING ORGANELLE CRYSTALLIZING AGENTS
  申请人：Kong, Qingzhong

  公开号：EP1294922A2

  公开（公告）日：2003-03-26
• TREATING CANCER USING ORGANELLE CRYSTALLIZING AGENTS
  申请人：Kong, Qingzhong

  公开号：EP1294922B1

  公开（公告）日：2010-04-14
• Vaginal Indicator to Detect Biomarkers of Good Health
  申请人：Martin Stephanie M.

  公开号：US20120130195A1

  公开（公告）日：2012-05-24

  A diagnostic kit for biomarkers of beneficial vaginal health is described. The kit includes a first detection zone within which a D-lactic acid detection signal is capable of being generated, wherein the presence or quantity of D-lactic acid, is determinable from the D-lactic acid detection signal. The kit further includes a second detection zone within which a hydrogen peroxide detection signal is capable of being generated, wherein the presence or quantity of hydrogen peroxide, is determinable from the hydrogen peroxide detection signal.