N-[4-[3-ethoxy-5-(3-fluorophenyl)-1,2,4-triazol-1-yl]phenyl]-2-thiophen-2-ylacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[4-[3-ethoxy-5-(3-fluorophenyl)-1,2,4-triazol-1-yl]phenyl]-2-thiophen-2-ylacetamide
• 化学式: C₂₂H₁₉FN₄O₂S
• 分子量: 422.5
• InChiKey: UHTSBFJBGUPWDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  97.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors
  申请人：Famulok Michael

  公开号：US20090105286A1

  公开（公告）日：2009-04-23

  The invention relates to drugs and the use thereof, wherein said drugs contain compounds selected from a group comprising general formulas (1), (2), (3) and (4) and/or enantiomers, diastereomers or the pharmaceutically acceptable salts thereof. Said drugs are used for treating autoimmune and tumoral diseases and/or for immunosuppresion.
• USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY
  申请人：Famulok Michael

  公开号：US20100048594A1

  公开（公告）日：2010-02-25

  The invention relates to compounds selected from among the group comprising general formulas (1), (2), (3), and/or (4) and/or the enantiomers, diastereomers, and derivatives thereof, and the pharmaceutically acceptable salts thereof for producing a medicament used for therapeutically and/or preventively treating disease and pathological conditions linked to regulation of the insulin and/or insulin-like growth factor (IGF) signalling pathway and/or for chemically inducing longevity.
• COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY
  申请人：Li Dean

  公开号：US20100222401A1

  公开（公告）日：2010-09-02

  Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis by modulating a signaling pathway delineated herein are described. Moreover, methods for producing and screening compounds and compositions capable of modulating the signaling pathway described herein, inhibiting vascular permeability, and inhibiting pathologic angiogenesis are also provided.
• US8163788B2
  申请人：——

  公开号：US8163788B2

  公开（公告）日：2012-04-24
• [DE] VERWENDUNG VON CYTOHESIN-INHIBITOREN ZUR CHEMISCHEN INDUKTION VON LANGLEBIGKEIT<br/>[EN] USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY<br/>[FR] UTILISATION D'INHIBITEURS DE LA CYTOHÉSINE POUR L'INDUCTION CHIMIQUE DE LONGÉVITÉ
  申请人：UNIV BONN

  公开号：WO2008058995A2

  公开（公告）日：2008-05-22

  [EN] The invention relates to compounds selected from among the group comprising general formulas (1), (2), (3), and/or (4) and/or the enantiomers, diastereomers, and derivatives thereof, and the pharmaceutically acceptable salts thereof for producing a medicament used for therapeutically and/or preventively treating diseases and pathological conditions linked to regulation of the insulin and/or insulin-like growth factor (IGF) signaling pathway and/or for chemically inducing longevity.
  [FR] L'invention concerne les composés choisis dans le groupe contenant les formules générales (1), (2), (3) et/ou (4) et/ou leurs énantiomères, diastéréomères, dérivés et leurs sels pharmaceutiquement compatibles pour la production d'un médicament destiné au traitement thérapeutique et/ou prophylactique de maladies et d'états pathologiques qui sont en liaison avec une régulation de la voie de signalisation de l'insuline et/ou du facteur de croissance insulinomimétrique IGF et/ou pour l'induction chimique de longévité.
  [DE] Die Erfindung betrifft die Verbindungen ausgewählt aus der Gruppe umfassend die allgemeinen Formeln (1), (2), (3) und/oder (4) und/oder deren Enantiomere, Diastereomere, Derivate sowie deren pharmazeutisch verträgliche Salze zur Herstellung eines Arzneimittels zur therapeutischen und/oder prophylaktischen Behandlung von Erkrankungen und pathologischen Zuständen, die mit einer Regulation des Insulin- und/oder IGF-(Insulin-like growth factor) Signalwegs in Zusammenhang stehen und/oder zur chemischen Induktion von Langlebigkeit.