N-benzyloxycarbonyl-DL-cysteine | 53907-29-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-benzyloxycarbonyl-DL-cysteine
• 英文别名: 2-benzyloxycarbonylamino-3-mercaptopropanoic acid；2-(Phenylmethoxycarbonylamino)-3-sulfanylpropanoic acid
• CAS: 53907-29-2
• 化学式: C₁₁H₁₃NO₄S
• 分子量: 255.295
• InChiKey: UNLYAPBBIOKKDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  76.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[3-[[3-[3-(2,5-Dioxopyrrol-1-yl)propoxymethyl]-1-bicyclo[1.1.1]pentanyl]methoxy]propyl]pyrrole-2,5-dione 、 N-benzyloxycarbonyl-DL-cysteine 以 aq. phosphate buffer 为溶剂， 30.0 ℃ 、101.33 kPa 条件下， 以28 %的产率得到
  参考文献：
  名称：

  WO2023/135329

  摘要：

  公开号：
• 作为产物：
  描述：

  (R,S)-2-benzyloxycarbonylamino-3-(2-benzyloxycarbonylamino-carboxyethyl-disulfanyl)propanoic acid 在 三苯基膦 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 18.0h， 以54%的产率得到N-benzyloxycarbonyl-DL-cysteine
  参考文献：
  名称：

  A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity

  摘要：

  DOI：

  10.1016/j.ejmech.2022.114240

文献信息

• [EN] COMPOUNDS (CYSTEIN BASED LIPOPEPTIDES) AND COMPOSITIONS AS TLR2 AGONISTS USED FOR TREATING INFECTIONS, INFLAMMATIONS, RESPIRATORY DISEASES ETC.<br/>[FR] COMPOSÉS (LIPOPEPTIDES À BASE DE CYSTÉINE) ET COMPOSITIONS EN TANT QU'AGONISTES DES TLR2 UTILISÉS POUR TRAITER DES INFECTIONS, INFLAMMATIONS, MALADIES RESPIRATOIRES ENTRE AUTRES
  申请人：IRM LLC

  公开号：WO2011119759A1

  公开（公告）日：2011-09-29

  The invention provides a novel class of compounds viz. generally lipopeptides like Pam3CSK4, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 2. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness a vaccine.

  这项发明提供了一类新型化合物，即一般类似Pam3CSK4的脂肽类化合物，包括含有这类化合物的免疫原组合物和药物组合物，以及使用这类化合物治疗或预防与Toll样受体2相关的疾病或紊乱的方法。在一个方面，这些化合物可用作增强疫苗效果的佐剂。
• The Facile Production of N-Methyl Amino Acids via Oxazolidinones
  作者：Luigi Aurelio、Robert T. C. Brownlee、Andrew B. Hughes、Brad E. Sleebs

  DOI：10.1071/ch99082

  日期：——

  A range of oxazolidinones derived from N-carbamoylα-amino acids were prepared by an efficient method as key intermediatesin the synthesis of N-methyl amino acids and peptides.The method was readily applied to most α-amino acids except those withbasic side chains. The oxazolidinones were converted by reductive cleavageinto N-methyl α-amino acids.

  以N-氨基甲酰基α-氨基酸为原料，制备了一系列恶唑烷酮类化合物，作为合成N-甲基氨基酸和多肽的关键中间体。该方法适用于除碱性侧链以外的大多数α-氨基酸。恶唑烷酮通过还原裂解转化为N-甲基α-氨基酸。
• 6-deoxy-6-thioether-amino acid cyclodextrin derivative and preparation method thereof
  申请人：Qi Youmao

  公开号：US10017584B2

  公开（公告）日：2018-07-10

  6-deoxy-6-thioether-amino acid cyclodextrin derivative is obtained by condensing an amino acid derivative with halogenated cyclodextrin in presence of alkali. The 6-deoxy-6-thioether-amino acid cyclodextrin derivative includes 6-deoxysulfinyl-6-thioether-amino acid cyclodextrin derivative and 6-deoxysulfonyl-6-thioether-amino acid cyclodextrin derivative. Compounds provided are for reversing neuromuscular relaxation in patients and animals induced by muscular relaxants. The compounds are able to rapidly reverse and antagonize muscular relaxation induced by muscular relaxants and can be administrated in preparing a drug having an antagonist effect on muscular relaxation. The compounds have a general formula (I).

  6-脱氧-6-硫醚-氨基酸环糊精衍生物是由氨基酸衍生物与卤化环糊精在碱存在下缩合而成。6-脱氧-6-硫醚-氨基酸环糊精衍生物包括 6-脱氧亚磺酰基-6-硫醚-氨基酸环糊精衍生物和 6-脱氧磺酰基-6-硫醚-氨基酸环糊精衍生物。所提供的化合物用于逆转肌肉松弛剂诱导的患者和动物的神经肌肉松弛。这些化合物能够快速逆转和拮抗由肌肉松弛剂诱导的肌肉松弛，可以在制备对肌肉松弛有拮抗作用的药物时使用。这些化合物的通式为 (I)。
• COMPOUNDS (CYSTEIN BASED LIPOPEPTIDES) AND COMPOSITIONS AS TLR2 AGONISTS USED FOR TREATING INFECTIONS, INFLAMMATIONS, RESPIRATORY DISEASES ETC.
  申请人：IRM LLC

  公开号：EP2549990A1

  公开（公告）日：2013-01-30
• 6-Deoxy-6-Thioether-Amino Acid Cyclodextrin Derivative and Preparation Method Thereof
  申请人：Qi Youmao

  公开号：US20130244979A1

  公开（公告）日：2013-09-19

  6-deoxy-6-thioether-amino acid cyclodextrin derivative is obtained by condensing an amino acid derivative with halogenated cyclodextrin in presence of alkali. The 6-deoxy-6-thioether-amino acid cyclodextrin derivative includes 6-deoxysulfinyl-6-thioether-amino acid cyclodextrin derivative and 6-deoxysulfonyl-6-thioether-amino acid cyclodextrin derivative. Compounds provided are for reversing neuromuscular relaxation in patients and animals induced by muscular relaxants. The compounds are able to rapidly reverse and antagonize muscular relaxation induced by muscular relaxants and can be administrated in preparing a drug having an antagonist effect on muscular relaxation. The compounds have a general formula (I).