2-(4-methoxybenzylthio)-4,6-dimethylpyrimidine | 321680-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-methoxybenzylthio)-4,6-dimethylpyrimidine
• 英文别名: 2-((4-Methoxybenzyl)thio)-4,6-dimethylpyrimidine；2-[(4-methoxyphenyl)methylsulfanyl]-4,6-dimethylpyrimidine
• CAS: 321680-94-8
• 化学式: C₁₄H₁₆N₂OS
• 分子量: 260.36
• InChiKey: FXVXLSBCOXZDIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-methoxybenzylthio)-4,6-dimethylpyrimidine 、 4-甲氧基苯硼酸 在 四(三苯基膦)钯 、 噻吩-2-甲酸亚铜(I) 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以88%的产率得到嘧啶,2-(4-甲氧苯基)-4,6-二甲基-
  参考文献：
  名称：

  An Expeditious Route toward Pyrazine-Containing Nucleoside Analogues

  摘要：

  An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.

  DOI：

  10.1021/jo102089h

文献信息

• An Expeditious Route toward Pyrazine-Containing Nucleoside Analogues
  作者：Sachin G. Modha、Jalpa C. Trivedi、Vaibhav P. Mehta、Denis S. Ermolat’ev、Erik V. Van der Eycken

  DOI：10.1021/jo102089h

  日期：2011.2.4

  An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.