methyl 3-[4-(ethoxycarbonyl)phenyl]-2-(4-methoxyphenyl)-indole-5-carboxylate | 1196786-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: methyl 3-[4-(ethoxycarbonyl)phenyl]-2-(4-methoxyphenyl)-indole-5-carboxylate
• 英文别名: methyl 3-(4-ethoxycarbonylphenyl)-2-(4-methoxyphenyl)-1H-indole-5-carboxylate
• CAS: 1196786-12-5
• 化学式: C₂₆H₂₃NO₅
• 分子量: 429.472
• InChiKey: HIWXVTLVODWXOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  、 对碘苯甲酸乙酯 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以60%的产率得到methyl 3-[4-(ethoxycarbonyl)phenyl]-2-(4-methoxyphenyl)-indole-5-carboxylate
  参考文献：
  名称：

  An efficient, microwave-assisted, one-pot synthesis of indoles under Sonogashira conditions

  摘要：

  A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.07.075

文献信息

• An efficient, microwave-assisted, one-pot synthesis of indoles under Sonogashira conditions
  作者：Yu Chen、Nataliya A. Markina、Richard C. Larock

  DOI：10.1016/j.tet.2009.07.075

  日期：2009.10

  A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method. (C) 2009 Elsevier Ltd. All rights reserved.