6-Chloro-2-(4-chlorophenyl)-3-(piperidinomethyl)imidazo[1,2-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-Chloro-2-(4-chlorophenyl)-3-(piperidinomethyl)imidazo[1,2-a]pyridine
• 英文别名: 6-chloro-2-(4-chlorophenyl)-3-(piperidin-1-ylmethyl)imidazo[1,2-a]pyridine
• 化学式: C₁₉H₁₉Cl₂N₃
• 分子量: 360.3
• InChiKey: AYWWZSFNPKCEFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  20.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SLC2A TRANSPORTER INHIBITORS<br/>[FR] INHIBITEURS DU TRANSPORTEUR SLC2A
  申请人：IOMET PHARMA LTD

  公开号：WO2014187922A1

  公开（公告）日：2014-11-27

  Provided is a SLC2A class I transporter inhibitor compound for use in medicine, which compound comprises the following formula (I): wherein A and Z may be the same or different and are each independently selected from C, N, O and S; each X may be the same or different and is independently selected from C, N, O and S; R1 and R5 may be present or absent and may be the same or different and are each selected from H and a substituted or unsubstituted organic group; Z completes a ring with each X, each ring comprising from 3 to 8 ring atoms including the X, A, and Z, each ring atom being independently selected from C, N, O and S, and each ring atom being unsubstituted or independently substituted with H or a substituted or unsubstituted organic group; and wherein the bonds between all of the atoms in the rings including the X, A, and Z may independently be single bonds or double bonds, provided that when X or a ring atom is O or S the bonds to X are single bonds.

  提供了一种用于药物的SLC2A类I转运体抑制剂化合物，该化合物包括以下结构式（I）：其中A和Z可以相同也可以不同，分别独立地选自C、N、O和S；每个X可以相同也可以不同，独立地选自C、N、O和S；R1和R5可以存在也可以不存在，可以相同也可以不同，分别选自H和一个取代或未取代的有机基团；Z与每个X形成一个环，每个环包括从3到8个环原子，包括X、A和Z，每个环原子独立地选自C、N、O和S，并且每个环原子未取代或独立地取代为H或一个取代或未取代的有机基团；所有环中的原子之间的键包括X、A和Z可能独立地为单键或双键，但当X或环原子为O或S时，与X的键为单键。
• SLC2A TRANSPORTER INHIBITORS
  申请人：IOMET PHARMA LTD.

  公开号：US20160120863A1

  公开（公告）日：2016-05-05

  Provided is a SLC2A class I transporter inhibitor compound for use in medicine, which compound comprises the following formula: wherein A and Z may be the same or different and are each independently selected from C, N, O and S; each X may be the same or different and is independently selected from C, N, O and S; R 1 and R 5 may be present or absent and may be the same or different and are each selected from H and a substituted or unsubstituted organic group; Z completes a ring with each X, each ring comprising from 3 to 8 ring atoms including the X, A, and Z, each ring atom being independently selected from C, N, O and S, and each ring atom being unsubstituted or independently substituted with H or a substituted or unsubstituted organic group; and wherein the bonds between all of the atoms in the rings including the X, A, and Z may independently be single bonds or double bonds, provided that when X or a ring atom is O or S the bonds to X are single bonds.

  提供了一种用于医药的SLC2A类I转运体抑制剂化合物，该化合物包括以下结构式：其中A和Z可以相同或不同，且分别独立地选自C、N、O和S；每个X可以相同或不同，且独立地选自C、N、O和S；R1和R5可以存在或不存在，可以相同或不同，且分别选自H和取代或未取代的有机基团；Z与每个X形成环，每个环包括从3到8个环原子，包括X、A和Z，每个环原子独立地选自C、N、O和S，并且每个环原子未取代或独立地取代H或取代或未取代的有机基团；其中，包括X、A和Z在内的所有环中的原子之间的键可以独立地为单键或双键，但当X或环原子为O或S时，与X的键为单键。