4-[2-(Acridin-9-ylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-2-amino-butyric acid | 77273-65-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[2-(Acridin-9-ylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-2-amino-butyric acid
• 英文别名: 5-[[3-Acridin-9-ylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-amino-5-oxopentanoic acid
• CAS: 77273-65-5
• 化学式: C₂₃H₂₄N₄O₆S
• 分子量: 484.533
• InChiKey: GXDFGUOOAMBVBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  197
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  glutathion 、 安啶 以 甲醇 为溶剂， 生成 N-(4-氨基-3-甲氧基苯基)甲磺酰胺 、 4-[2-(Acridin-9-ylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-2-amino-butyric acid
  参考文献：
  名称：

  Kinetics and mechanism of thiolytic cleavage of the antitumor compound 4'-[(9-acridinyl)amino]methanesulfon-m-anisidide

  摘要：

  DOI：

  10.1021/jo00135a009

文献信息

• BATCH DEVICES FOR THE REDUCTION OF COMPOUNDS FROM BIOLOGICAL COMPOSITIONS CONTAINING CELLS AND METHODS OF USE
  申请人：——

  公开号：US20010018179A1

  公开（公告）日：2001-08-30

  Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.

  提供了一种方法和装置，用于在基于细胞的生物组成物中减少低分子量化合物的浓度，同时基本维持所需的生物活性。该装置包括高度多孔吸附剂颗粒，并且这些吸附剂颗粒被惰性基质固定。
• Absorbents and devices for the reduction of small organic compounds from blood products
  申请人：Cerus Corporation

  公开号：EP1508345A1

  公开（公告）日：2005-02-23

  The present invention relates to a system for use in treating a blood product containing a pathogen inactivating agent comprising a biocompatible housing and an adsorbent medium having (1) adsorbent resin particles capable of adsorbing the pathogen inactivating agent, and (2) an inert matrix in which the adsorbent resin particles are immobilized; wherein the immobilized adsorbent particles have a diameter from about 100 µm to about 1200 µm when the system is configured as a batch apparatus, and the immobilized adsorbent particles have a diameter from about 1 µm to about 200 µm when the system is configured as a flow-through apparatus; and wherein said blood product substantially maintains a desired biological activity after treatment with said system.

  本发明涉及一种用于处理含有病原体灭活剂的血液制品的系统，该系统包括生物相容性外壳和吸附介质，吸附介质具有(1)能够吸附病原体灭活剂的吸附树脂颗粒，和(2)固定吸附树脂颗粒的惰性基质；其中，当系统配置为间歇式装置时，固定吸附剂颗粒的直径约为 100 µm 至约 1200 µm，而当系统配置为流动式装置时，固定吸附剂颗粒的直径约为 1 µm 至约 200 µm；并且，在使用所述系统处理后，所述血液制品基本上保持了所需的生物活性。
• Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
  申请人：——

  公开号：US20020045228A1

  公开（公告）日：2002-04-18

  Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.

  本发明提供了降低含有细胞的生物组合物中低分子量化合物浓度的方法和装置，同时基本保持了生物组合物所需的生物活性。该装置包括高多孔性吸附剂颗粒，吸附剂颗粒被惰性基质固定。
• ADSORBING PATHOGEN-INACTIVATING COMPOUNDS WITH POROUS PARTICLES IMMOBILIZED IN A MATRIX
  申请人：——

  公开号：US20040185553A9

  公开（公告）日：2004-09-23

  Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.

  本发明提供了降低含有细胞的生物组合物中低分子量化合物浓度的方法和装置，同时基本保持了生物组合物所需的生物活性。该装置包括高多孔性吸附剂颗粒，吸附剂颗粒被惰性基质固定。
• ABSORBING PATHOGEN-INACTIVATING COMPOUNDS WITH POROUS PARTICLES IMMOBILIZED IN A MATRIX
  申请人：Hei J. Derek

  公开号：US20050142542A1

  公开（公告）日：2005-06-30

  Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 1 μm to about 200 μm. The matrix can be fibrous, and the particles can have a surface area greater than 750 m 2 /g and a pore diameter between about 25 and 800 Å. The device can be used to adsorb and remove a pathogen-inactivating compound that is a nucleic acid-binding compound such as psoralen, an acridine derivative or a dye from a biological composition such as a blood product.

  提供了降低生物组合物中低分子量化合物浓度的方法和装置，同时基本保持生物组合物所需的生物活性。该装置包括高多孔性吸附剂颗粒，吸附剂颗粒被惰性基质固定。含有颗粒的基质装在一个外壳中，颗粒的直径从约 1 μm 到约 200 μm。基质可以是纤维状的，颗粒的表面积可以大于 750 m 2 /g，孔径在约 25 到 800 Å 之间。该装置可用于吸附和去除生物组合物（如血液制品）中的病原体灭活化合物，该化合物是一种核酸结合化合物，如补骨脂素、吖啶衍生物或染料。