2,6-Bis-acetylamino-heptanedioic acid | 91216-98-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,6-Bis-acetylamino-heptanedioic acid
• 英文别名: 2,6-Diacetamidoheptanedioic acid；2,6-diacetamidoheptanedioic acid
• CAS: 91216-98-7
• 化学式: C₁₁H₁₈N₂O₆
• 分子量: 274.274
• InChiKey: DVQWRWPDUJOTNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,6-Bis-acetylamino-heptanedioic acid 在 cobalt(II) chloride hexahydrate 、 sodium carbonate 作用下， 以 1,4-二氧六环 、 aq. phosphate buffer 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 301.5h， 生成 (2R,6S)-dibenzyl 2-(benzyloxycarbonylamino)-6-((tert-butoxy)carbonylamino)heptanedioate
  参考文献：
  名称：

  Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses

  摘要：

  特征性的分子Mycobacterium肽聚糖片段已全面合成，并显示了它们通过Nod1和Nod2较弱的免疫刺激作用。

  DOI：

  10.1039/c5ob02145f

文献信息

• Kinetic resolution of unnatural and rarely occurring amino acids: enantioselective hydrolysis of N-acyl amino acids catalyzed by acylase I
  作者：H. Keith Chenault、Juergen Dahmer、George M. Whitesides

  DOI：10.1021/ja00198a055

  日期：1989.8
• ALLOSTERIC CHAPERONES AND USES THEREOF
  申请人：Fondazione Telethon

  公开号：US20150147309A1

  公开（公告）日：2015-05-28

  The present invention relates to an allosteric non-inhibitory chaperone of the lysosomal acid alpha-glucosidase (GAA) for use in the treatment of a pathological condition characterized by a deficiency of the lysosomal acid alpha-glucosidase (GAA), to pharmaceutical composition thereof, to a method for increasing the activity of GAA in a subject and to a method for identifying an allosteric non-inhibitory chaperone for GAA.
• ELASTASE INHIBITORS
  申请人：The California Institute for Biomedical Research

  公开号：US20170144998A1

  公开（公告）日：2017-05-25

  Described herein are compounds, compositions, and methods of their use for the treatment of a lung or intestinal disease.
• [EN] LUNG LOCALIZED INHIBITORS OF ALPHA(V)BETA 6<br/>[FR] INHIBITEURS D'ALPHA (V) BÊTA 6, LOCALISÉS DANS LES POUMONS
  申请人：CALIFORNIA INST BIOMEDICAL RES

  公开号：WO2015179823A2

  公开（公告）日：2015-11-26

  Described herein are compounds, compositions, and methods of their use treatment of a lung disease.
• Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses
  作者：Qianqian Wang、Yusuke Matsuo、Ambara R. Pradipta、Naohiro Inohara、Yukari Fujimoto、Koichi Fukase

  DOI：10.1039/c5ob02145f

  日期：——

  CharacteristicMycobacteriumpeptidoglycan fragments were comprehensively synthesized and their weaker immunostimulationviaNod1 and Nod2 was shown.

  特征性的分子Mycobacterium肽聚糖片段已全面合成，并显示了它们通过Nod1和Nod2较弱的免疫刺激作用。