ethyl 2-(2-methyl-1H-indol-3-yl)-3-phenyl-3-(2,2,2-trifluoroacetoxy)propanoate | 1609115-43-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl 2-(2-methyl-1H-indol-3-yl)-3-phenyl-3-(2,2,2-trifluoroacetoxy)propanoate
• 英文别名: ethyl (2R,3S)-2-(2-methyl-1H-indol-3-yl)-3-phenyl-3-(2,2,2-trifluoroacetyl)oxypropanoate
• CAS: 1609115-43-6
• 化学式: C₂₂H₂₀F₃NO₄
• 分子量: 419.4
• InChiKey: KRAWDRMZANYGNH-RTBURBONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-methyl-1-(2-methyl-1H-3-indolyl)ethyl (4-methylphenyl)sulfone 在 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 异丙醇 为溶剂， 反应 12.5h， 生成 ethyl 2-(2-methyl-1H-indol-3-yl)-3-phenyl-3-(2,2,2-trifluoroacetoxy)propanoate
  参考文献：
  名称：

  The Concise Synthesis of Spiro-Cyclopropane Compounds via the Dearomatization of Indole Derivatives

  摘要：

  A concise synthesis of spiro-cyclopropane compounds from indole derivatives and sulfur ylides has been developed via a dearomatization strategy. Moreover, the spiro-cyclopropane compounds could be conveniently transformed to rearomatized indole derivatives in the presence of acids.

  DOI：

  10.1021/ol500948r

文献信息

• The Concise Synthesis of Spiro-Cyclopropane Compounds via the Dearomatization of Indole Derivatives
  作者：Jing Luo、Bo Wu、Mu-Wang Chen、Guo-Fang Jiang、Yong-Gui Zhou

  DOI：10.1021/ol500948r

  日期：2014.5.16

  A concise synthesis of spiro-cyclopropane compounds from indole derivatives and sulfur ylides has been developed via a dearomatization strategy. Moreover, the spiro-cyclopropane compounds could be conveniently transformed to rearomatized indole derivatives in the presence of acids.