N-(2,2-dimethylpropyl)glycinamide | 915702-21-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2,2-dimethylpropyl)glycinamide
• 英文别名: 2-amino-N-(2,2-dimethylpropyl)acetamide
• CAS: 915702-21-5
• 化学式: C₇H₁₆N₂O
• 分子量: 144.217
• InChiKey: ZYESSNDFOLUING-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2,2-dimethylpropyl)glycinamide 、 N-[2-(cyanomethyl)-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl]-1H-imidazole-1-carboxamide 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以68%的产率得到N~2~-({[2-(cyanomethyl)-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl]amino}carbonyl)-N-(2,2-dimethylpropyl)glycinamide
  参考文献：
  名称：

  WO2006/125805

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl {2-[(2,2-dimethylpropyl)amino]-2-oxoethyl}carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 以100%的产率得到N-(2,2-dimethylpropyl)glycinamide
  参考文献：
  名称：

  WO2006/125805

  摘要：

  公开号：

文献信息

• Process for producing optically active alpha-amino acid and optically active alpha-amino acid amine
  申请人：——

  公开号：US20030171597A1

  公开（公告）日：2003-09-11

  The present invention provides a process for efficiently producing an optically active &agr;-amino acid and an optically active &agr;-amino acid amide. After contacting with cells or processed cells thereof having an ability to asymmetrically hydrolyse, a water solvent is substituted with at least one solvent selected from the group consisting of linear, branched, or cyclic alcohol having 3 or more carbon atoms and the optically active &agr;-amino acid is preferentially precipitated from the alcohol solution. The addition of basic compounds, particularly potassium compounds to the alcohol solution containing the optically active &agr;-amino acid amide, which is obtained after the separation of the optically active &agr;-amino acid, enables the purification of the amide without the inclusion of amino acid into amino acid amide. Thus, the amide is subjected to the step of racemization and then recycled.

  本发明提供了一种高效生产光学活性α-氨基酸和光学活性α-氨基酸酰胺的方法。与具有不对称水解能力的细胞或经处理的细胞接触后，用至少一种来自直链、支链或环状醇中选择的溶剂替代水溶剂，并使光学活性α-氨基酸优先从醇溶液中沉淀。将碱性化合物，特别是钾化合物加入到含有光学活性α-氨基酸酰胺的醇溶液中，该酰胺在分离光学活性α-氨基酸后获得，使酰胺能够在不包括氨基酸转化为氨基酸酰胺的情况下纯化。因此，酰胺经过消旋步骤后再进行回收利用。
• Indole and Benzimidazole Derivatives
  申请人：Boyce Rustum S.

  公开号：US20080317744A1

  公开（公告）日：2008-12-25

  The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

  本发明涉及新的吲哚和苯并咪唑化合物及其药学上可接受的盐、酯或前药，新化合物与药学上可接受的载体的组合物，以及新化合物的用途。本发明的化合物具有以下一般式：
• Thiazole Derivatives and Use Thereof
  申请人：Quattropani Anna

  公开号：US20080188531A1

  公开（公告）日：2008-08-07

  The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

  本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植、移植排斥或肺损伤。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE ALPHA-AMINO ACID AND OPTICALLY ACTIVE ALPHA-AMINO ACID AMIDE
  申请人：Mitsubishi Rayon Co., Ltd.

  公开号：EP1300392A1

  公开（公告）日：2003-04-09

  The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells thereof having an ability to asymmetrically hydrolyse, a water solvent is substituted with at least one solvent selected from the group consisting of linear, branched, or cyclic alcohol having 3 or more carbon atoms and the optically active α-amino acid is preferentially precipitated from the alcohol solution. The addition of basic compounds, particularly potassium compounds to the alcohol solution containing the optically active α-amino acid amide, which is obtained after the separation of the optically active α-amino acid, enables the purification of the amide without the inclusion of amino acid into amino acid amide. Thus, the amide is subjected to the step of racemization and then recycled.

  本发明提供了一种高效生产光学活性α-氨基酸和光学活性α-氨基酸酰胺的工艺。在与具有不对称水解能力的细胞或其加工细胞接触后，水溶剂被至少一种选自具有 3 个或更多碳原子的线性、支链或环状醇的溶剂所取代，光学活性 α-氨基酸优先从醇溶液中析出。 在分离光学活性 α-氨基酸后得到的含有光学活性 α-氨基酸酰胺的醇溶液中加入碱性化合物，特别是钾化合物，可以在氨基酸酰胺中不加入氨基酸的情况下提纯酰胺。因此，酰胺经过消旋化步骤后便可回收利用。
• MATERIAL FOR BLOOD PURIFICATION
  申请人：Toray Industries, Inc.

  公开号：EP3513821A1

  公开（公告）日：2019-07-24

  An object of the present invention is to provide a material for blood purification having the capability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification, the material containing a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.

  本发明的目的是提供一种血液净化材料，该材料具有去除细胞因子和活化白细胞-活化血小板复合物的能力。本发明提供了一种血液净化材料，该材料含有一种水不溶性材料，其中具有酰胺基团和氨基的配体与基质结合，其中酰胺基团的含量为每 1 克水不溶性材料干重 3.0 至 7.0 毫摩尔；氨基的含量为每 1 克水不溶性材料干重 1.0 至 7.0 毫摩尔。