2-(4-bromophenyl)imidazo[1,2-a]pyrimidine-3-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-bromophenyl)imidazo[1,2-a]pyrimidine-3-carbaldehyde
• 化学式: C₁₃H₈BrN₃O
• mdl: MFCD04966862
• 分子量: 302.13
• InChiKey: NXJFHZOLRHNMMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-溴苯乙酮 在 N-溴代丁二酰亚胺(NBS) 、 三氯氧磷 作用下， 以 甘油 为溶剂， 反应 0.23h， 生成 2-(4-bromophenyl)imidazo[1,2-a]pyrimidine-3-carbaldehyde
  参考文献：
  名称：

  甘油中2-芳基咪唑并[1,2-a]嘧啶-3-甲醛的便捷高效微波辅助合成

  摘要：

  摘要 2-苯基咪唑并[1,2-a]嘧啶与（Vilsmeier-Haack试剂）反应合成2-芳基咪唑并[1,2-a]嘧啶-3-甲醛的简单高效方法在 400 瓦、90 °C 的微波辐射下，甘油作为绿色反应介质存在。反应条件温和、收率高、反应时间短、反应曲线干净、避免使用有毒催化剂、有害有机溶剂、废料少是以往采用的方法的优点。

  DOI：

  10.1080/00397911.2022.2158746

文献信息

• Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US11208422B2

  公开（公告）日：2021-12-28

  The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle.

  本申请涉及新型咪唑吡啶基或咪唑嘧啶基取代的、桥接的式(I)1,4-二氮杂环庚烷衍生物，涉及其制备工艺，涉及其单独使用或组合使用以治疗和/或预防疾病，涉及其用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防呼吸系统疾病，包括与睡眠有关的呼吸系统疾病，如阻塞性睡眠呼吸暂停和中枢性睡眠呼吸暂停以及打鼾。式（I）中，环 Q 代表桥接的 1，4-二氮杂环。
• SUBSTITUTED BRIDGED DIAZEPANE DERIVATIVES AND USE THEREOF AS TASK-1 AND TASK-3 INHIBITORS
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US20200140461A1

  公开（公告）日：2020-05-07

  The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle
• DIAZABICYCLIC SUBSTITUTED IMIDAZOPYRIMIDINES AND THEIR USE FOR THE TREATMENT OF BREATHING DISORDERS
  申请人：Bayer Aktiengesellschaft

  公开号：US20220017540A1

  公开（公告）日：2022-01-20

  The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.