4-amino-2-fluoro-α-methylphenethylamine | 103834-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-2-fluoro-α-methylphenethylamine
• 英文别名: 4-(2-Aminopropyl)-3-fluoroaniline
• CAS: 103834-90-8
• 化学式: C₉H₁₃FN₂
• 分子量: 168.214
• InChiKey: ADGRLNHEJFDROV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(dibenzylamino)-2-fluorobenzaldehyde 在 palladium on activated charcoal 乙酸铵 、 盐酸 、 lithium aluminium tetrahydride 、 氢气 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 为溶剂， 反应 7.0h， 生成 4-amino-2-fluoro-α-methylphenethylamine
  参考文献：
  名称：

  Selective monoamine oxidase inhibitors. 4. 4-Aminophenethylamine derivatives with neuron-selective action

  摘要：

  Nine 4-aminophenethylamine derivatives were synthesized and tested for monoamine oxidase (MAO) inhibitory effects with particular attention to their selectivity for MAO within monoaminergic neurons in the rat brain. All compounds selectively inhibited the A form of MAO in vitro. Some of the compounds inhibited the MAO within the monoaminergic neurons at much lower doses than those required for inhibition of MAO within other cells in vivo. The most potent compounds in this respect were 4-amino-2-fluoro-alpha-methylphenethylamine (5) and 4-amino-2-chloro-alpha-methylphenethylamine (4).

  DOI：

  10.1021/jm00161a020

文献信息

• Selective monoamine oxidase inhibitors. 4. 4-Aminophenethylamine derivatives with neuron-selective action
  作者：Lennart Florvall、Ingrid Fagervall、Anna Lena Ask、Svante B. Ross

  DOI：10.1021/jm00161a020

  日期：1986.11

  Nine 4-aminophenethylamine derivatives were synthesized and tested for monoamine oxidase (MAO) inhibitory effects with particular attention to their selectivity for MAO within monoaminergic neurons in the rat brain. All compounds selectively inhibited the A form of MAO in vitro. Some of the compounds inhibited the MAO within the monoaminergic neurons at much lower doses than those required for inhibition of MAO within other cells in vivo. The most potent compounds in this respect were 4-amino-2-fluoro-alpha-methylphenethylamine (5) and 4-amino-2-chloro-alpha-methylphenethylamine (4).