DDD00175837 | 68160-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: DDD00175837
• 英文别名: 5-[2]pyridylmethylene-barbituric acid；5-[2]Pyridylmethylen-barbitursaeure；5-(2-Pyridylmethylidene)hexahydropyrimidine-2,4,6-trione；5-(pyridin-2-ylmethylidene)-1,3-diazinane-2,4,6-trione
• CAS: 68160-61-2
• 化学式: C₁₀H₇N₃O₃
• mdl: MFCD00118253
• 分子量: 217.184
• InChiKey: XOWWEYYMXKVOOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吡啶-2-甲醛 、 巴比妥酸 在 水 作用下， 生成 DDD00175837
  参考文献：
  名称：

  Profft et al., Journal fur praktische Chemie (Leipzig 1954), 1955, vol. <4>2, p. 147,159

  摘要：

  DOI：

文献信息

• COMPOUNDS FOR USE IN CANCER THERAPY
  申请人：Connor James R.

  公开号：US20150065531A1

  公开（公告）日：2015-03-05

  Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell. The methods are effective on tumor cells that are resistant to drugs such as temozolomide, doxorubicin, and geldanamycin, as well as non-resistant tumor cells. Further provided are barbiturate and thiobarbiturates diene compounds for use in treating cancer, and uses, methods and compositions relating to these compounds.

  提供了用于治疗疾病的方法和成分，特别是用于治疗癌症，优选为耐药性癌症和/或放射线耐药性癌症。这些化合物可用于减小哺乳动物主体的肿瘤大小，并诱导肿瘤细胞凋亡。这些方法对于耐药性药物如替莫唑胺、多柔比星和格尔达纳霉素以及非耐药性肿瘤细胞都有效。此外，还提供了用于治疗癌症的巴比妥和硫代巴比妥二烯化合物，以及与这些化合物相关的用途、方法和组合物。
• BARBITURATE AND THIOBARBITURATE COMPOUNDS FOR USE IN CANCER THERAPY
  申请人：NUHOPE, LLC

  公开号：US20180134691A1

  公开（公告）日：2018-05-17

  Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell. The methods are effective on tumor cells that are resistant to drugs such as temozolomide, doxorubicin, and geldanamycin, as well as non-resistant tumor cells. Further provided are barbiturate and thiobarbiturates diene compounds for use in treating cancer, and uses, methods and compositions relating to these compounds.
• US9878998B2
  申请人：——

  公开号：US9878998B2

  公开（公告）日：2018-01-30
• US9994554B2
  申请人：——

  公开号：US9994554B2

  公开（公告）日：2018-06-12
• Profft et al., Journal fur praktische Chemie (Leipzig 1954), 1955, vol. <4>2, p. 147,159
  作者：Profft et al.

  DOI：——

  日期：——