1-((2R,5R)-4-Ethenesulfonyl-5-hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione | 202259-92-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 1-((2R,5R)-4-Ethenesulfonyl-5-hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione
• 英文别名: 1-[(2R,5R)-4-ethenylsulfonyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione
• CAS: 202259-92-5
• 化学式: C₁₁H₁₂N₂O₆S
• 分子量: 300.292
• InChiKey: VEOWAKDYEDZEIU-GMSGAONNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  环己胺 、 苯甲酰氯 、 1-((2R,5R)-4-Ethenesulfonyl-5-hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione 在 吡啶 作用下， 生成 Benzoic acid (1R,3R,3aS,7aS)-7-cyclohexyl-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4,4-dioxo-octahydro-2-oxa-4λ⁶-thia-7-aza-inden-3-ylmethyl ester
  参考文献：
  名称：

  Sugar-Modified Uridine Bisvinyl Sulfone:  Synthesis of a Bifunctionalized Nucleoside Michael Acceptor and Its Use in Stereoselective Tandem Cyclization

  摘要：

  A bisvinyl sulfone functionality is incorporated into the carbohydrate moiety of uridine to synthesize 6 (or 7) which is a bifunctionalized nucleoside Michael acceptor and has the potential to form covalent bond with biological nucleophiles. This compound could be used to generate a large number and a new class of bicyclic S,S-dioxidethiazine derivatives 8-12 in stereoselective fashion. Compound 6 is also useful for the synthesis of a wide variety of monosubstituted compounds 13-15. The structures of compounds 8-12 have been established unambiguously by synthesising the core structure 28 in a stereospecific fashion.

  DOI：

  10.1021/jo9705576
• 作为产物：
  描述：

  5’-O-三苯甲基尿苷-2’,3’-来苏-环氧化物 在 吡啶 、 sodium hydroxide 、 magnesium monoperoxyphthalate hexahydrate 、 溶剂黄146 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 8.25h， 生成 1-((2R,5R)-4-Ethenesulfonyl-5-hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Sugar-Modified Uridine Bisvinyl Sulfone:  Synthesis of a Bifunctionalized Nucleoside Michael Acceptor and Its Use in Stereoselective Tandem Cyclization

  摘要：

  A bisvinyl sulfone functionality is incorporated into the carbohydrate moiety of uridine to synthesize 6 (or 7) which is a bifunctionalized nucleoside Michael acceptor and has the potential to form covalent bond with biological nucleophiles. This compound could be used to generate a large number and a new class of bicyclic S,S-dioxidethiazine derivatives 8-12 in stereoselective fashion. Compound 6 is also useful for the synthesis of a wide variety of monosubstituted compounds 13-15. The structures of compounds 8-12 have been established unambiguously by synthesising the core structure 28 in a stereospecific fashion.

  DOI：

  10.1021/jo9705576

文献信息

• Sugar-Modified Uridine Bisvinyl Sulfone:  Synthesis of a Bifunctionalized Nucleoside Michael Acceptor and Its Use in Stereoselective Tandem Cyclization
  作者：Sanjib Bera、Graham J. Langley、Tanmaya Pathak

  DOI：10.1021/jo9705576

  日期：1998.3.1

  A bisvinyl sulfone functionality is incorporated into the carbohydrate moiety of uridine to synthesize 6 (or 7) which is a bifunctionalized nucleoside Michael acceptor and has the potential to form covalent bond with biological nucleophiles. This compound could be used to generate a large number and a new class of bicyclic S,S-dioxidethiazine derivatives 8-12 in stereoselective fashion. Compound 6 is also useful for the synthesis of a wide variety of monosubstituted compounds 13-15. The structures of compounds 8-12 have been established unambiguously by synthesising the core structure 28 in a stereospecific fashion.