cyclohex-2-enyl(2-methoxyphenyl)dimethylsilane | 1233348-29-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: cyclohex-2-enyl(2-methoxyphenyl)dimethylsilane
• 英文别名: Cyclohex-2-en-1-yl-(2-methoxyphenyl)-dimethylsilane
• CAS: 1233348-29-2
• 化学式: C₁₅H₂₂OSi
• 分子量: 246.425
• InChiKey: MCFIYEUXEAIIOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.72
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-苯基-1,2,4-三唑啉-3,5-二酮 、 cyclohex-2-enyl(2-methoxyphenyl)dimethylsilane 以 二氯甲烷 为溶剂， 以55%的产率得到11-[(2-methoxyphenyl)dimethylsilanyl]-4-phenyl-2,4,6-triazatricyclo[5.3.1.0(2,6)]undecane-3,5-dione
  参考文献：
  名称：

  On the [3 + 2] Annulation of Cyclic Allylsilanes with N-Phenyltriazolinedione: An Enantio- and Diastereoselective Synthesis of cis-1,3-Diaminocyclitols

  摘要：

  Improved conditions were found to trigger [3 + 2] annulation of cyclic allylsilanes with N-phenyltriazolinedione (PTAD); the products from this reaction were readily tailored into cis-1,3-diaminocyclitols in highly enantioenriched form with full stereochemical control of up to four contiguous stereogenic centers.

  DOI：

  10.1021/jo100724w
• 作为产物：
  描述：

  chloro(2-methoxyphenyl)dimethylsilane 、 环己烯 在 正丁基锂 、 四甲基乙二胺 、 potassium tert-butylate 作用下， 以 正己烷 为溶剂， 以70%的产率得到cyclohex-2-enyl(2-methoxyphenyl)dimethylsilane
  参考文献：
  名称：

  On the [3 + 2] Annulation of Cyclic Allylsilanes with N-Phenyltriazolinedione: An Enantio- and Diastereoselective Synthesis of cis-1,3-Diaminocyclitols

  摘要：

  Improved conditions were found to trigger [3 + 2] annulation of cyclic allylsilanes with N-phenyltriazolinedione (PTAD); the products from this reaction were readily tailored into cis-1,3-diaminocyclitols in highly enantioenriched form with full stereochemical control of up to four contiguous stereogenic centers.

  DOI：

  10.1021/jo100724w

文献信息

• On the [3 + 2] Annulation of Cyclic Allylsilanes with <i>N</i>-Phenyltriazolinedione: An Enantio- and Diastereoselective Synthesis of <i>cis</i>-1,3-Diaminocyclitols
  作者：Raudra T. Dey、Tarun K. Sarkar

  DOI：10.1021/jo100724w

  日期：2010.7.2

  Improved conditions were found to trigger [3 + 2] annulation of cyclic allylsilanes with N-phenyltriazolinedione (PTAD); the products from this reaction were readily tailored into cis-1,3-diaminocyclitols in highly enantioenriched form with full stereochemical control of up to four contiguous stereogenic centers.