8-geranylapigenin | 134955-26-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 8-geranylapigenin
• 英文别名: 8-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one；8-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
• CAS: 134955-26-3
• 化学式: C₂₅H₂₆O₅
• 分子量: 406.478
• InChiKey: KMHJTUNINWRWFT-FRKPEAEDSA-N

物化性质

• 沸点：
  642.5±55.0 °C(Predicted)
• 密度：
  1.245±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-hydroxy-7-(methoxymethoxy)-2-(4-(methoxymethoxy)phenyl)-4H-chromen-4-one 在 盐酸 、 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 4.25h， 生成 8-geranylapigenin
  参考文献：
  名称：

  Fukai, Toshio; Nomura, Taro, Heterocycles, 1991, vol. 32, # 3, p. 499 - 510

  摘要：

  DOI：

文献信息

• ISOGENIC HUMAN CELL LINES COMPRISING MUTATED CANCER ALLELES AND PROCESS USING THE CELL LINES
  申请人：Bardelli Alberto

  公开号：US20120115896A1

  公开（公告）日：2012-05-10

  Isogenic human cell lines comprising at least one mutated cancer allele under the control of the cell line endogenous promoter, which corresponds to the wild-type cancer allele promoter are disclosed, as well as an in vitro process for determining sensitivity/resistance of a patient suffering from a tumor to a pharmacological agent comprising the following steps: a) identifying at least one mutated cancer allele in a tissue affected by a tumor of said patient; b) providing an isogenic human cell line representative of the tissue, wherein the cell line comprises at least the identified mutated cancer allele, which is under the control of the cell line endogenous promoter corresponding to the wild-type cancer allele promoter; c) putting in contact said cell line with the pharmacological agent; d) determining a variation of proliferation, apoptosis or cytotoxicity of the cell line in presence of the pharmacological agent; wherein the variation of proliferation, apoptosis car cytotoxicity indicative of the sensitivity/resistance of the patient tumor to the pharmacological agent.
• Fukai, Toshio; Nomura, Taro, Heterocycles, 1991, vol. 32, # 3, p. 499 - 510
  作者：Fukai, Toshio、Nomura, Taro

  DOI：——

  日期：——