4-(2-Methoxy-5-prop-2-enylphenyl)-2-(1-methylpyrazol-3-yl)phenol | 1360445-20-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-Methoxy-5-prop-2-enylphenyl)-2-(1-methylpyrazol-3-yl)phenol
• 英文别名: 4-(2-methoxy-5-prop-2-enylphenyl)-2-(1-methylpyrazol-3-yl)phenol
• CAS: 1360445-20-0
• 化学式: C₂₀H₂₀N₂O₂
• 分子量: 320.391
• InChiKey: PUEVSMLDJYRZQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  47.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-Methoxy-5-prop-2-enylphenyl)-2-(1-methylpyrazol-3-yl)phenol 在 三氟二甲基硫醚络合物 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 18.0h， 以95%的产率得到5-allyl-3'-(1-methyl-1H-pyrazol-3-yl)-[1,1'-biphenyl]-2,4'-diol
  参考文献：
  名称：

  Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity

  摘要：

  A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.015
• 作为产物：
  描述：

  1-(5-Bromo-2-methoxyphenyl)prop-2-yn-1-ol 在 Jones reagent 、 四(三苯基膦)钯 、 三氟二甲基硫醚络合物 作用下， 以 乙二醇二甲醚 、 乙醇 、 二氯甲烷 、 1,2-二氯乙烷 、 丙酮 为溶剂， 反应 25.17h， 生成 4-(2-Methoxy-5-prop-2-enylphenyl)-2-(1-methylpyrazol-3-yl)phenol
  参考文献：
  名称：

  Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity

  摘要：

  A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.015

文献信息

• Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity
  作者：Vemula Praveen Kumar、R. Gajendra Reddy、Duc Duy Vo、Sumana Chakravarty、Srivari Chandrasekhar、René Grée

  DOI：10.1016/j.bmcl.2011.12.015

  日期：2012.2

  A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. (C) 2011 Elsevier Ltd. All rights reserved.