4-(thiazol-2-ylamino)butan-2-one | 1268829-65-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(thiazol-2-ylamino)butan-2-one
• 英文别名: 4-(1,3-Thiazol-2-ylamino)butan-2-one
• CAS: 1268829-65-7
• 化学式: C₇H₁₀N₂OS
• 分子量: 170.235
• InChiKey: FXGSEWZGXKGKLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基噻唑 、 丁烯酮 反应 4.0h， 以91%的产率得到4-(thiazol-2-ylamino)butan-2-one
  参考文献：
  名称：

  Green, efficient and practical Michael addition of arylamines to α,β-unsaturated ketones

  摘要：

  The aza-Michael addition of aromatic amines to alpha,beta-unsaturated ketones was carried out effectively at room temperature in good to excellent yields without any catalyst or solvent. It was significant that part of adducts could be collected in almost quantitative yield without column chromatography. This procedure offered a green, efficient, and practical approach for the synthesis of beta-amino ketones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.082

文献信息

• Green, efficient and practical Michael addition of arylamines to α,β-unsaturated ketones
  作者：Ran Jiang、Dan-Hua Li、Jing Jiang、Xiao-Ping Xu、Tao Chen、Shun-Jun Ji

  DOI：10.1016/j.tet.2011.03.082

  日期：2011.5

  The aza-Michael addition of aromatic amines to alpha,beta-unsaturated ketones was carried out effectively at room temperature in good to excellent yields without any catalyst or solvent. It was significant that part of adducts could be collected in almost quantitative yield without column chromatography. This procedure offered a green, efficient, and practical approach for the synthesis of beta-amino ketones. (C) 2011 Elsevier Ltd. All rights reserved.