1-(3-chlorophenyl)-4-(4-fluorophenyl)-1H-1,2,3-triazole | 1452162-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3-chlorophenyl)-4-(4-fluorophenyl)-1H-1,2,3-triazole
• 英文别名: 1-(3-Chlorophenyl)-4-(4-fluorophenyl)triazole；1-(3-chlorophenyl)-4-(4-fluorophenyl)triazole
• CAS: 1452162-55-8
• 化学式: C₁₄H₉ClFN₃
• 分子量: 273.697
• InChiKey: JXBHZHHNQHWYQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氯苯胺 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 7.13h， 生成 1-(3-chlorophenyl)-4-(4-fluorophenyl)-1H-1,2,3-triazole
  参考文献：
  名称：

  Cu(II)-anchored functionalized mesoporous SBA-15: An efficient and recyclable catalyst for the one-pot Click reaction in water

  摘要：

  A new pyridine-imine functionalized mesoporus silica (SBA-15) has been synthesized through the Schiff-base condensation of 3-aminopropyl functionalized SBA-15 with 2-pyridinecarboxaldehyde followed by the grafting of Cu(II) onto it resulting a new Cu@Pylm-SBA-15 material. 20-hexagonally ordered mesophases of the material are analyzed by small-angle powder X-ray diffractions (PXRD) and transmission electron microscopic (TEM) image analyses. The Cu(ll)-anchored mesoporous material, Cu@PyIm-SBA-15 showed excellent catalytic activity towards the one pot click reaction between azides formed in situ from the corresponding amines and acetylenes in water at 0 C to room temperature resulting a wide variety of 1,4-disubstituted 1,2,3-triazoles. The catalyst has been recycled for five cycles without any appreciable loss of catalytic activity and also without any appreciable Cu-leaching, suggesting a future potential of this novel mesoporous catalyst for the synthesis of 1,4-disubstituted 1,2,3-triazoles. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2014.01.027

文献信息

• Polymer anchored Cu(ii) complex: an efficient and recyclable catalytic system for the one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles starting from anilines in water
  作者：Susmita Roy、Tanmay Chatterjee、Sk. Manirul Islam

  DOI：10.1039/c3gc41114a

  日期：——

  An efficient procedure for the one-pot synthesis of 1,4-disubstituted 1,2,3-triazole derivatives has been developed by the ‘click’ reaction of azides generated in situ from anilines or amines and terminal acetylenes catalyzed by the polymer anchored Cu(II) catalyst in water without using any additives. The polymer anchored Cu(II) catalyst was synthesized and its catalytic activity was evaluated in

  一锅合成1,4-二取代的有效方法 1,2,3-三唑 衍生产品是通过以下方式的“点击”反应开发的： 叠氮化物从原位产生苯胺 或者 胺类 和终端 乙炔 由...催化 聚合物锚固的铜（II）催化剂 在 水不使用任何添加剂。这聚合物锚固的铜（II）催化剂合成并首次在Huisgen [3 + 2]环加成反应中评估其催化活性。该协议具有以下优点：催化剂 装载，高收率，清洁反应，可回收利用 催化剂，在 水，不使用有害有机物 溶剂 用于产品纯化和一锅合成 三唑 从 苯胺 或者 胺类。
• Synthesis of silver–graphene nanocomposite and its catalytic application for the one-pot three-component coupling reaction and one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles in water
  作者：Noor Salam、Arjyabaran Sinha、Anupam Singha Roy、Paramita Mondal、Nikhil R. Jana、Sk Manirul Islam

  DOI：10.1039/c3ra47466f

  日期：——

  reaction between in situ generated azides (derived from anilines or amines) and terminal acetylenes. This solid silver–graphene catalyst has been characterized by TEM, Raman, XRD and UV-Visible absorption spectra. The developed catalyst is air-stable, inexpensive, easy to prepare and can be facilely recovered and reused five times without significant decrease in activity and selectivity.

  已经通过简单的化学路线合成了具有银纳米颗粒的石墨烯基复合材料，并且已经通过一锅法测试了其催化活性用于多组分反应和点击反应。这种银-石墨烯纳米复合材料在室温下对醛，炔烃和胺之间的三组分偶联（A 3偶联）和通过点击反应一锅法合成1,4-二取代的1,2,3-三唑显示出出色的催化活性。原位之间生成的叠氮化物（衍生自苯胺或胺）和末端乙炔。该固体银-石墨烯催化剂已通过TEM，拉曼光谱，XRD和UV-可见吸收光谱进行了表征。所开发的催化剂是空气稳定的，便宜的，易于制备的，并且可以容易地回收和重复使用五次而不会显着降低活性和选择性。