4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide | 1415242-24-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide
• 英文别名: 4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]-2-methyl-N-[(4R)-2-ethyl-3-oxoisoxazolidin-4-yl]benzamide；4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]-N-[(4R)-2-ethyl-3-oxo-1,2-oxazolidin-4-yl]-2-methylbenzamide
• CAS: 1415242-24-8
• 化学式: C₂₄H₂₁Cl₂F₃N₂O₄
• 分子量: 529.343
• InChiKey: CCRPSJIHKIDQOD-PPUHSXQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]-2-methylbenzoic acid 、 (4R)-4-amino-2-ethylisoxazolidin-3-one hydrochloride 在 氯化亚砜 、 N,N-二甲基甲酰胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide
  参考文献：
  名称：

  [EN] INSECTICIDAL COMPOUNDS
  [FR] COMPOSÉS INSECTICIDES

  摘要：

  本发明提供了以下式（I）的化合物：其中A1、A2、A3和A4彼此独立地为C-H、C-R5或氮；B1--B2--B3--B4为-CH2-C=N-CH2-、-CH2-N-CH2-CH2-、-CH2-C=CH-0-或-CH=C-CH2-0-；G1为氧或硫；L为单键或C1-C8烷基；R1为氢、C1-C8烷基、C1-C8烷基羰基、C1-C8烷氧基、C2-C8烯基、C2-C8炔基、C1-C8烷氧基-C1-C8烷基、芳基或被1至3个R6取代的芳基，或R1为杂环烷基或被1至3个R6或C1-C8烷氧羰基取代的杂环烷基；R2为氢、C1-C8卤代烷基或C1-C8烷基；R3为C1-C8卤代烷基；R4为芳基或被1至3个R6取代的芳基，或R4为杂环烷基或被1至3个R6取代的杂环烷基；Y1为CR7R8、C=O或C=S；Y2、Y3和Y4独立地为CR7R8、C=0、C=S、N-R9、O、S、SO或SO2；其中由Y1、Y2、Y3和Y4形成的环中至少有两个相邻的环原子为杂原子；每个R7和R8独立地为氢、卤素、C1-C8烷基或C1-C8卤代烷基；而R5、R6、R7、R8和R9如权利要求中所定义。本发明还涉及制备这些化合物的过程和中间体，包括这些化合物的杀虫剂、杀螨剂、杀线虫剂和杀软体动物剂组合物，以及使用这些化合物控制昆虫、螨类、线虫和软体动物害虫的方法。

  公开号：

  WO2012163959A1

文献信息

• INSECTICIDAL COMPOUNDS
  申请人：Cassayre Jerome Yves

  公开号：US20140107056A1

  公开（公告）日：2014-04-17

  The present invention provides compounds of formula (I): wherein A 1 , A 2 , A 3 and A 4 are independently of one another C—H, C—R 5 , or nitrogen; B 1 —B 2 —B 3 —B 4 is —CH 2 —C═N—CH 2 —, —CH 2 —N—CH 2 —CH 2 —, —CH 2 —C═CH-0- or —CH═C—CH 2 -0-; G 1 is oxygen or sulfur; L is a single bond or C 1 -C 8 alkylene; R 1 is hydrogen, C 1 -C 8 alkyl, C 1 -C 8 alkylcarbonyl-, C 1 -C 8 alkoxy, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 1 -C 8 alkoxy-C 1 -C 8 alkyl, aryl or aryl substituted by one to three R 6 , or R 1 is heterocyclyl or heterocyclyl substituted by one to three R 6 or C 1 -C 8 alkoxycarbonyl-; R 2 is hydrogen, C 1 -C 8 haloalkyl or C 1 -C 8 alkyl; R 3 is C 1 -C 8 haloalkyl; R 4 is aryl or aryl substituted by one to three R 6 , or R 4 is heterocyclyl or heterocyclyl substituted by one to three R 6 ; Y 1 is CR 7 R 8 , C═O or C═S; Y 2 , Y 3 and Y 4 are independently CR 7 R 8 , C=0, C═S, N—R 9 , O, S, SO or SO 2 ; wherein at least two adjacent ring atoms in the ring formed by Y 1 , Y 2 , Y 3 and Y 4 are heteroatoms; each R 7 and R 8 is independently hydrogen, halogen, C 1 -C 8 alkyl, or C 1 -C 8 haloalkyl; and R 5 , R 6 , R 7 , R 8 and R 9 are as defined in the claims. The invention also relates to processes and intermediates for preparing these compounds, to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising these compounds and to methods of using these compounds to control insect, acarine, nematode and mollusc pests.

  本发明提供了式（I）的化合物：其中，A1，A2，A3和A4分别独立地为C-H、C-R5或氮；B1-B2-B3-B4为-CH2-C═N-CH2-、-CH2-N-CH2-CH2-、-CH2-C═CH-0-或-CH═C-CH2-0-；G1为氧或硫；L为单键或C1-C8烷基；R1为氢、C1-C8烷基、C1-C8烷基羰基、C1-C8烷氧基、C2-C8烯基、C2-C8炔基、C1-C8烷氧基-C1-C8烷基、芳基或被1至3个R6取代的芳基，或R1为含杂环基或被1至3个R6或C1-C8烷氧羰基取代的含杂环基；R2为氢、C1-C8卤代烷基或C1-C8烷基；R3为C1-C8卤代烷基；R4为芳基或被1至3个R6取代的芳基，或R4为含杂环基或被1至3个R6取代的含杂环基；Y1为CR7R8、C═O或C═S；Y2、Y3和Y4分别为CR7R8、C=0、C═S、N-R9、O、S、SO或SO2；其中由Y1、Y2、Y3和Y4形成的环中至少有两个相邻的环原子是杂原子；每个R7和R8分别独立地为氢、卤素、C1-C8烷基或C1-C8卤代烷基；R5、R6、R7、R8和R9的定义如权利要求书所述。本发明还涉及制备这些化合物的方法和中间体，涉及包含这些化合物的杀虫剂、杀螨剂、杀线虫剂和杀软体动物剂的组合物，以及使用这些化合物控制昆虫、螨、线虫和软体动物害虫的方法。
• Insecticidal compounds
  申请人：Syngenta Participations AG

  公开号：US10869477B2

  公开（公告）日：2020-12-22

  The present invention provides compounds of formula (I): wherein A1, A2, A3 and A4 are independently of one another C—H, C—R5, or nitrogen; B1-B2-B3-B4 is —CH2—C═N—CH2—, —CH2—N—CH2—CH2—, —CH2—C═CH—O— or —CH═C—CH2—O—; G1 is oxygen or sulfur; L is a single bond or C1-C8alkylene; R1 is hydrogen, C1-C8alkyl, C1-C8alkylcarbonyl-, C1-C8alkoxy, C2-C8alkenyl, C2-C8alkynyl, C1-C8alkoxy-C1-C8alkyl, aryl or aryl substituted by one to three R6, or R1 is heterocyclyl or heterocyclyl substituted by one to three R6 or C1-C8alkoxycarbonyl-; R2 is hydrogen, C1-C8haloalkyl or C1-C8alkyl; R3 is C1-C8haloalkyl; R4 is aryl or aryl substituted by one to three R6, or R4 is heterocyclyl or heterocyclyl substituted by one to three R6; Y1 is CR7R8, C—O or C═S; Y2, Y3 and Y4 are independently CR7R8, C═O, C═S, N—R9, O, S, SO or SO2; wherein at least two adjacent ring atoms in the ring formed by Y1, Y2, Y3 and Y4 are heteroatoms; each R7 and R8 is independently hydrogen, halogen, C1-C8alkyl, or C1-C8haloalkyl; and R5, R6, R7, R8 and R9 are as defined in the claims. The invention also relates to processes and intermediates for preparing these compounds, to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising these compounds and to methods of using these compounds to control insect, acarine, nematode and mollusc pests.

  本发明提供了式 (I) 的化合物： 其中 A1、A2、A3 和 A4 相互独立地为 C-H、C-R5 或氮； B1-B2-B3-B4 是 -CH2-C═N-CH2-、-CH2-N-CH2-CH2-、-CH2-C═CH-O- 或 -CH═C-CH2-O-； G1 是氧或硫； L 是单键或 C1-C8 烷基； R1 是氢、C1-C8烷基、C1-C8烷基羰基、C1-C8烷氧基、C2-C8烯基、C2-C8炔基、C1-C8烷氧基-C1-C8烷基、芳基或被一至三个 R6 取代的芳基，或者 R1 是杂环基或被一至三个 R6 取代的杂环基或 C1-C8烷氧基羰基； R2 是氢、C1-C8 卤代烷基或 C1-C8 烷基； R3 是 C1-C8 卤代烷基； R4 是芳基或被一至三个 R6 取代的芳基，或 R4 是杂环基或被一至三个 R6 取代的杂环基； Y1 是 CR7R8、C-O 或 C═S； Y2、Y3 和 Y4 独立地为 CR7R8、C═O、C═S、N-R9、O、S、SO 或 SO2； 其中 Y1、Y2、Y3 和 Y4 形成的环中至少两个相邻的环原子是杂原子； 每个 R7 和 R8 独立地是氢、卤素、C1-C8 烷基或 C1-C8 卤代烷基； 以及 R5、R6、R7、R8 和 R9 如权利要求中所定义。 本发明还涉及制备这些化合物的工艺和中间体，涉及包含这些化合物的杀虫、杀螨、杀线虫和杀软体动物组合物，以及使用这些化合物防治昆虫、螨虫、线虫和软体动物害虫的方法。
• US9545106B2
  申请人：——

  公开号：US9545106B2

  公开（公告）日：2017-01-17
• US9913471B2
  申请人：——

  公开号：US9913471B2

  公开（公告）日：2018-03-13
• [EN] INSECTICIDAL COMPOUNDS<br/>[FR] COMPOSÉS INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2012163959A1

  公开（公告）日：2012-12-06

  The present invention provides compounds of formula (I): wherein A1, A2, A3 and A4 are independently of one another C-H, C-R5, or nitrogen; B1--B2--B3--B4 is -CH2-C=N-CH2-, -CH2-N-CH2-CH2-, -CH2-C=CH-0- or -CH=C-CH2-0-; G1 is oxygen or sulfur; L is a single bond or C1-C8alkylene; R1 is hydrogen, C1-C8alkyl, C1-C8alkylcarbonyl-, C1-C8alkoxy, C2-C8alkenyl, C2-C8alkynyl, C1-C8alkoxy- C1-C8alkyl, aryl or aryl substituted by one to three R6, or R1 is heterocyclyl or heterocyclyl substituted by one to three R6 or C1-C8alkoxycarbonyl-; R2 is hydrogen, C1-C8haloalkyl or C1-C8alkyl; R3 is C1-C8haloalkyl; R4 is aryl or aryl substituted by one to three R6, or R4 is heterocyclyl or heterocyclyl substituted by one to three R6; Y1 is CR7R8, C=O or C=S; Y2, Y3 and Y4 are independently CR7R8, C=0, C=S, N-R9, O, S, SO or SO2; wherein at least two adjacent ring atoms in the ring formed by Y1, Y2, Y3 and Y4 are heteroatoms; each R7 and R8 is independently hydrogen, halogen, C1-C8alkyl, or C1-C8haloalkyl; and R5, R6, R7, R8 and R9 are as defined in the claims. The invention also relates to processes and intermediates for preparing these compounds, to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising these compounds and to methods of using these compounds to control insect, acarine, nematode and mollusc pests.

  本发明提供了以下式（I）的化合物：其中A1、A2、A3和A4彼此独立地为C-H、C-R5或氮；B1--B2--B3--B4为-CH2-C=N-CH2-、-CH2-N-CH2-CH2-、-CH2-C=CH-0-或-CH=C-CH2-0-；G1为氧或硫；L为单键或C1-C8烷基；R1为氢、C1-C8烷基、C1-C8烷基羰基、C1-C8烷氧基、C2-C8烯基、C2-C8炔基、C1-C8烷氧基-C1-C8烷基、芳基或被1至3个R6取代的芳基，或R1为杂环烷基或被1至3个R6或C1-C8烷氧羰基取代的杂环烷基；R2为氢、C1-C8卤代烷基或C1-C8烷基；R3为C1-C8卤代烷基；R4为芳基或被1至3个R6取代的芳基，或R4为杂环烷基或被1至3个R6取代的杂环烷基；Y1为CR7R8、C=O或C=S；Y2、Y3和Y4独立地为CR7R8、C=0、C=S、N-R9、O、S、SO或SO2；其中由Y1、Y2、Y3和Y4形成的环中至少有两个相邻的环原子为杂原子；每个R7和R8独立地为氢、卤素、C1-C8烷基或C1-C8卤代烷基；而R5、R6、R7、R8和R9如权利要求中所定义。本发明还涉及制备这些化合物的过程和中间体，包括这些化合物的杀虫剂、杀螨剂、杀线虫剂和杀软体动物剂组合物，以及使用这些化合物控制昆虫、螨类、线虫和软体动物害虫的方法。