3,6-Dichloro-2'-isopropyloxy-4'-methylflavone | 70460-45-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,6-Dichloro-2'-isopropyloxy-4'-methylflavone
• 英文别名: 3,6-dichloro-2-(4-methyl-2-propan-2-yloxyphenyl)chromen-4-one
• CAS: 70460-45-6
• 化学式: C₁₉H₁₆Cl₂O₃
• 分子量: 363.2
• InChiKey: PWGZOUCWGRTPSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 5-pyridyl-1, 3-azole compounds, process for producing the same and use there of
  申请人：Ohkawa Shigenori

  公开号：US20090048307A1

  公开（公告）日：2009-02-19

  An optionally N-oxidized compound represented by the formula: wherein R 1 represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R 2 represents an aromatic group, R 3 represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR 4 (R 4 represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A 3 receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A 3 receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.

  一种可选择氧化的化合物，其化学式表示为：其中R1表示氢，碳氢化合物，杂环，氨基，酰基，R2表示芳香基团，R3表示氢，吡啶基，芳香烃，X表示氧，可选择氧化的硫，Y表示键，氧，可选择氧化的硫，一个由公式NR4（R4表示氢，碳氢化合物或酰基）表示的基团和Z表示键或二价无环碳氢化合物，或其盐具有出色的腺苷A3受体拮抗活性，并用作预防或治疗与腺苷A3受体相关的疾病的药剂。此外，该化合物（I）或其盐具有p38 MAP激酶抑制活性和TNF-α抑制活性，并用作预防或治疗与p38 MAP激酶和TNF-α相关的疾病的药剂。
• Methods for reducing intraocular pressure
  申请人：——

  公开号：US20030153626A1

  公开（公告）日：2003-08-14

  A method for decreasing intraocular pressure by administering an A 3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen. These agents, by inhibiting influx or promoting efflux of aqueous humor, can be used to treat glaucoma.

  一种通过施用 A 3 亚型腺苷受体拮抗剂、钙调素拮抗剂或抗雌激素（如他莫昔芬）来降低眼压的方法。这些药物通过抑制房水的流入或促进房水的流出，可用于治疗青光眼。
• EFFECTIVE DELIVERY OF CROSS-SPECIES A3 ADENOSINE-RECEPTOR ANTAGONISTS TO REDUCE INTRAOCULAR PRESSURE
  申请人：The Trustees of the University of Pennsylvania

  公开号：EP2076267A2

  公开（公告）日：2009-07-08
• Method of using vasoconstrictive agents during energy-based tissue therapy
  申请人：Podhajsky Ronald J.

  公开号：US20070208042A1

  公开（公告）日：2007-09-06

  A mammal undergoing an energy-based therapy is treated by administering at least one vasoconstrictive agent to the mammal prior to or during the procedure. The at least one vasoconstrictive agent is added in amounts sufficient to reduce or prevent vasodilation. This treatment method increases or promotes the size of the coagulation zone created after energy-based therapy.
• Method of using adenosine receptor blockers during tissue ablation
  申请人：Podhajsky J. Ronald

  公开号：US20070207979A1

  公开（公告）日：2007-09-06

  A mammal undergoing an ablation procedure is treated for symptoms associated with adenosine by administering one or more adenosine receptor antagonists to the mammal prior to or during the procedure.