Methyl 2,3-dihydroxy-2-methylpropanoate | 1195311-85-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Methyl 2,3-dihydroxy-2-methylpropanoate
• 英文别名: Methyl 2,3-dihydroxy-2-methylbutanoate
• CAS: 1195311-85-3
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: XKXDXWAQHUEJGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl-2,3-dihydroxy-2-methyl-propanoate 在 氰化钾 作用下， 以 甲醇 为溶剂， 反应 20.0h， 以53%的产率得到Methyl 2,3-dihydroxy-2-methylpropanoate
  参考文献：
  名称：

  Process for making bicalutamide and intermediates thereof

  摘要：

  Bicalutamide及/或其中间体是通过使用对氟苯磺酸盐作为试剂制备的。

  公开号：

  US20040068135A1

文献信息

• Clerodendrin I, a New Neoclerodane Diterpenoid from<i>Clerodendron trichotomum</i>
  作者：Kunji KAWAI、Ritsuo NISHIDA、Hiroshi FUKAMI

  DOI：10.1271/bbb.63.1795

  日期：1999.1

  A new neoclerodane diterpenoid, clerodendrin I, was isolated from leaves of Clerodendron trichotomum as a feeding stimulant of the turnip sawfly, Athalia rosae ruficornis, and characterized as a threo epimer of clerodendrin F in the 2,3-diacetoxy-2-methylbutanoyloxy moiety at the C-3β position.

  从三疣帚柄菊的叶片中分离出一种新的新蛇床子烷二萜类化合物--clerodendrin I，它是芜菁锯蝇（Athalia rosae ruficornis）的一种取食刺激物，其特征是clerodendrin F在C-3β位置的2,3-二乙酰氧基-2-甲基丁酰氧基分子中的一个三元表聚体。
• Composition for pattern formation, and pattern-forming method
  申请人：JSR CORPORATION

  公开号：US11370872B2

  公开（公告）日：2022-06-28

  A composition for pattern formation includes a first polymer, a second polymer and a solvent. The first polymer includes: a first block including a first structural unit derived from a substituted or unsubstituted styrene; and a second block including a second structural unit other than the first structural unit. The second polymer includes: the first structural unit; and a group bonding to at least one end of a main chain thereof and including a polar group. The polar group is preferably a hydroxy group or a carboxyl group. A number average molecular weight of the second polymer is preferably no greater than 6,000. A mass ratio of the second polymer to the first polymer is preferably no less than 0.15 and no greater than 0.4. The solvent preferably comprises a compound comprising a hydroxyl group and an alkyl ester group.

  一种用于图案形成的组合物包括第一聚合物、第二聚合物和溶剂。第一种聚合物包括：第一嵌段，其中包括源自取代或未取代苯乙烯的第一结构单元；以及第二嵌段，其中包括与第一结构单元不同的第二结构单元。第二种聚合物包括：第一种结构单元；以及与主链至少一端结合并包括极性基团的基团。极性基团最好是羟基或羧基。第二种聚合物的平均分子量最好不大于 6000。第二种聚合物与第一种聚合物的质量比最好不小于 0.15 也不大于 0.4。溶剂最好由包含羟基和烷基酯基的化合物组成。
• COMPOSITION FOR PATTERN FORMATION, AND PATTERN-FORMING METHOD
  申请人：JSR Corporation

  公开号：US20190135967A1

  公开（公告）日：2019-05-09

  A composition for pattern formation includes a first polymer, a second polymer and a solvent. The first polymer includes: a first block including a first structural unit derived from a substituted or unsubstituted styrene; and a second block including a second structural unit other than the first structural unit. The second polymer includes: the first structural unit; and a group bonding to at least one end of a main chain thereof and including a polar group. The polar group is preferably a hydroxy group or a carboxyl group. A number average molecular weight of the second polymer is preferably no greater than 6,000. A mass ratio of the second polymer to the first polymer is preferably no less than 0.15 and no greater than 0.4. The solvent preferably comprises a compound comprising a hydroxyl group and an alkyl ester group.
• Process for making bicalutamide and intermediates thereof
  申请人：——

  公开号：US20040068135A1

  公开（公告）日：2004-04-08

  Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.

  Bicalutamide及/或其中间体是通过使用对氟苯磺酸盐作为试剂制备的。