(2S)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid | 172823-92-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid
• 英文别名: 2-(S)-(2,2-dimethyl-5-oxo-1.3-dioxolan-4-(R)-yl)-4-methylpentanoic acid
• CAS: 172823-92-6
• 化学式: C₁₁H₁₈O₅
• 分子量: 230.261
• InChiKey: ZUOVLWXPFQJYLF-JGVFFNPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid 、 五氟苯酚 、 在 水 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以to yield the title compound (1.39 g, 74%)的产率得到2-(S)-(2,2-dimethyl-5-oxo-1.3-dioxolan-4-(R)-yl)-4-methylpentanoic acid pentafluorophenyl ester
  参考文献：
  名称：

  Cytokine inhibiting imidazole substituted hydroxamic acid derivatives

  摘要：

  本发明涉及一系列新型咪唑取代羟肟酸衍生物，以及它们作为基质降解金属蛋白酶抑制剂的有用组合物，特别是胶原酶。

  公开号：

  US05665753A1
• 作为产物：
  描述：

  (R)-(+)-苹果酸二异丙酯 生成 (2S)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid
  参考文献：
  名称：

  [EN] N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF
  [FR] DERIVES N-HYDROXYAMIDE ET LEUR APPLICATION

  摘要：

  本发明涉及式（I）的N-羟基酰胺衍生物及其用途，特别是用于治疗和/或预防自身免疫性疾病、炎症性疾病、心血管疾病、神经退行性疾病、癌症、呼吸道疾病和纤维化，包括多发性硬化症、关节炎、肺气肿、慢性阻塞性肺病、肝脏和肺部纤维化。

  公开号：

  WO2006010751A1

文献信息

• N-Hydroxyamide Derivatives and Use Thereof
  申请人：Swinnen Dominique

  公开号：US20080021028A1

  公开（公告）日：2008-01-24

  The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

  本发明涉及公式（I）的N-羟基酰胺衍生物及其用途，特别用于治疗和/或预防自身免疫性疾病、炎症性疾病、心血管疾病、神经退行性疾病、癌症、呼吸系统疾病和纤维化，包括多发性硬化症、关节炎、肺气肿、慢性阻塞性肺疾病、肝脏和肺纤维化。
• N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF
  申请人：Swinnen Dominique

  公开号：US20110263628A1

  公开（公告）日：2011-10-27

  The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

  本发明涉及公式（I）的N-羟基酰胺衍生物及其在特定领域的应用，尤其是用于治疗和/或预防自身免疫性疾病、炎症性疾病、心血管疾病、神经退行性疾病、癌症、呼吸系统疾病和纤维化，包括多发性硬化、关节炎、肺气肿、慢性阻塞性肺疾病、肝和肺纤维化。
• N-hydroxyamide derivatives and use thereof
  申请人：Merck Serono SA

  公开号：US08008302B2

  公开（公告）日：2011-08-30

  The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

  本发明涉及式（I）的N-羟基酰胺衍生物及其用途，特别是用于治疗和/或预防自身免疫性疾病、炎症性疾病、心血管疾病、神经退行性疾病、癌症、呼吸系统疾病和纤维化疾病，包括多发性硬化症、关节炎、肺气肿、慢性阻塞性肺疾病、肝和肺纤维化。
• PROTEIN BIOSENSORS, CROSS REACTIVE SENSOR ARRAYS AND METHODS OF USE THEREOF
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20150362490A1

  公开（公告）日：2015-12-17

  The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.

  本发明涉及基于寡核苷酸交叉反应传感器阵列的荧光蛋白生物传感器，其中包括选择性和非选择性蛋白质表面结合域用于蛋白质检测。不同蛋白质亚型与本发明的传感器的相互作用产生每种蛋白质的独特光学特征。独特的光学特征允许区分密切相关的蛋白质亚型，并在生物流体中诊断与蛋白质相关的疾病和障碍。
• Protein biosensors, cross reactive sensor arrays and methods of use thereof
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US10281459B2

  公开（公告）日：2019-05-07

  The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.

  本发明涉及基于寡核苷酸交叉反应传感器阵列的荧光蛋白生物传感器，该传感器阵列包括用于检测蛋白质的选择性和非选择性蛋白质表面结合域。不同蛋白质异构体与本发明传感器的相互作用可产生每种蛋白质的独特光学特征。这种独特的光学特征可用于区分密切相关的蛋白质异构体，诊断生物流体中与蛋白质相关的疾病。