N-cyclopropyl succinamic acid | 135449-70-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-cyclopropyl succinamic acid
• 英文别名: 4-(Cyclopropylamino)-4-oxobutanoic acid
• CAS: 135449-70-6
• 化学式: C₇H₁₁NO₃
• 分子量: 157.169
• InChiKey: ASJRDGPSQDCCBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丁二酸酐 、 cyclopropylamine hydrochloride 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以98%的产率得到N-cyclopropyl succinamic acid
  参考文献：
  名称：

  Glutamine analogues as potential antimalarials

  摘要：

  Various N-substituted derivatives of glutamine, asparagine, glutaramic, succinamic and maleamic acids have been synthesized and tested in vitro against Plasmodium falciparum. From these compounds, only the glutamine derivatives (1-3) were found to have low activity. Kinetic evaluation of 1-3 revealed that these compounds also act as competitive inhibitors of gamma-glutamyl transpeptidase (EC 2.3.2.2).

  DOI：

  10.1016/0223-5234(91)90030-q

文献信息

• INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER
  申请人：Wu Jie

  公开号：US20120034186A1

  公开（公告）日：2012-02-09

  Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throughput screen identified compounds that inhibit the PTP Shp2. Several compounds were identified that selectively inhibit Shp2 over Shp1 with low to sub-micromolar activity. Also disclosed are methods of inhibiting a protein tyrosine phosphatase in a cell and treating cancer through selective inhibition of Shp2.
• US7645771B2
  申请人：——

  公开号：US7645771B2

  公开（公告）日：2010-01-12
• US8623906B2
  申请人：——

  公开号：US8623906B2

  公开（公告）日：2014-01-07
• [EN] INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER<br/>[FR] INHIBITEURS D'ÉCHAFAUDAGE D'INDOLINE SHP-2 ET PROCÉDÉ DE TRAITEMENT DU CANCER
  申请人：H LEE MOFFIT CANCER CT AND RES

  公开号：WO2010121212A2

  公开（公告）日：2010-10-21

  Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throughput screen identified compounds that inhibit the PTP Shp2. Several compounds were identified that selectively inhibit Shp2 over Shp1 with low to sub-micromolar activity. Also disclosed are methods of inhibiting a protein tyrosine phosphatase in a cell and treating cancer through selective inhibition of Shp2.