N-(4,6-二甲基-2-吡啶基)苯甲酰胺 | 94843-50-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4,6-二甲基-2-吡啶基)苯甲酰胺
• 英文名称: N-(4,6-dimethylpyridin-2-yl)benzamide
• 英文别名: N-(4,6-Dimethyl-2-pyridinyl)benzamide
• CAS: 94843-50-2
• 化学式: C₁₄H₁₄N₂O
• mdl: MFCD01667431
• 分子量: 226.278
• InChiKey: NVKSBZOFCYGLHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  N-(4,6-二甲基-2-吡啶基)苯甲酰胺 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以93%的产率得到2-benzylamino-4,6-dimethylpyridine
  参考文献：
  名称：

  Non-acidic anti-inflammatory compounds: activity of N-(4,6-dimethyl-2-pyridinyl) benzamides and derivatives

  摘要：

  DOI：

  10.1016/0223-5234(90)90159-z
• 作为产物：
  描述：

  2-氨基-4,6-二甲基吡啶 、 苯乙炔 在 氧气 、 copper(l) chloride 作用下， 以 乙腈 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 12.0h， 以86%的产率得到N-(4,6-二甲基-2-吡啶基)苯甲酰胺
  参考文献：
  名称：

  铜（I）催化的2-氨基吡啶与末端炔烃的氧化CN偶联，具有可见光促进的CC键裂解作用

  摘要：

  描述了在室温下通过CC三键裂解在2-氨基吡啶和末端炔烃之间促进可见光促进的铜催化的需氧氧化CN偶联。该反应可以直接合成生物...

  DOI：

  10.1039/c6cc05506k

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• Synthesis and Central Dopaminergic Effects of N-(4,6-Dimethyl-2-pyridinyl)benzamides
  作者：Saïd Bouhayat、Sylvie Piessard、Guillaume Le Baut、Louis Sparfel、Jean-Yves Petit、François Piriou、Lucien Welin

  DOI：10.1021/jm50001a004

  日期：1985.5

  N-(4,6-Dimethyl-2-pyridinyl)benzamides 1-24 and the corresponding tertiary derivatives 29-33 were synthesized and studied for possible dopamine-inhibitory properties by testing their effect on motility of naive and reserpinized mice. Unlike the orthopramides, they failed to show any antidopaminergic properties, but some of the secondary derivatives showed instead effects of postsynaptic dopaminergic

  合成了N-（4,6-二甲基-2-吡啶基）苯甲酰胺1-24和相应的三级衍生物29-33，并通过测试它们对幼稚和再固定化小鼠运动的影响来研究其对多巴胺的抑制作用。与原丙酰胺不同，它们没有显示出任何抗多巴胺能的特性，但是一些二级衍生物反而显示了突触后多巴胺能激动作用。随后研究了后一种化合物对利血平诱导的运动障碍的阿扑吗啡逆转以及对大鼠脑HVA水平的影响。化合物11在6-羟基多巴胺损伤的小鼠中引起的相反盘旋表明涉及直接机制。
• Non-acidic antiinflammatory compounds II. Synthesis and activity of 6-amino-2,4-lutidine derivatives
  作者：J ROBERT、S ROBERTPIESSARD、M DUFLOS、G LEBAUT、E KHETTAB、N GRIMAUD、J PETIT、L WELIN

  DOI：10.1016/0223-5234(94)90107-4

  日期：——

  Benzamides I, phenylalkanamides II and cinnamamides III are structurally related to the antiinflammatory N-(4,6-dimethylpyridin-2-yl)benzamide 1. These were synthesized and the transformation of the 2-aminopyridine nucleus of benzamides I into a 2-imino-1,2-dihydropyridine structure (compounds IV) was also carried out. Of the 49 new derivatives, the 3-fluorobenzamide 9 was the most potent in the oral treatment of carrageenen-induced peripheral edema; IC50 = 12.2 mg.kg(-1). It was 3 times as active as benzamide 1, but the latter nevertheless had a better therapeutic index (LD(50)/IC50) of 52 against 23. Benzamide 1, a non-acidic antiinflammatory compound devoid of any blocking activity on cyclooxygenase, markedly reduces the production of reactive oxygen species in rat peritoneal macrophages. This compound probably acts at the membrane, perhaps by interference with transmembrane events.
• Synthesis and characterization of N-(2-pyridyl)benzamide-based nickel complexes and their activity for ethylene oligomerization
  作者：Wen-Hua Sun、Wen Zhang、Tielong Gao、Xiubo Tang、Liyi Chen、Yan Li、Xianglin Jin

  DOI：10.1016/j.jorganchem.2003.12.022

  日期：2004.3

  A series of N-(2-pyridyl)benzamides (1)-(11) and their nickel complexes, [N-(2-pyridyl)benzamide]dinickel(II) di-mu-bromide dibromide (12)-(16) and (aryl)[N-(2-pyridyl)benzamido](triphenylphosphine)nickel(II) (17)-(24), were synthesized and characterized. The single-crystal X-ray analysis revealed that 12 and 14 are binuclear nickel complexes bridged by bromine atoms and each nickel atom adopts a distorted trigonal bipyramidal geometry. The key feature of the complexes 17, 19 and 23 is each has a six-membered nickel chelate ring including a deprotonated secondary nitrogen atom and an O-donor atom. The nickel complexes show moderate to high catalytic activity for ethylene oligomerization with methylaluminoxane (MAO) as cocatalyst. The activity of 12-16/MAO systems is up to 3.3 x 10(4) g mol(-1) h(-1) whereas for 17-24/MAO systems it is up to 4.94 x 10(5) g mol(-1) atm(-1) h(-1). The influence of Al/Ni molar ratio, reaction temperature, reaction period and PPh3/Ni molar ratio on catalytic activity was investigated. (C) 2004 Elsevier B.V. All rights reserved.
• Robert, Jean-Michel; Rideau, Odile; Robert-Piessard, Sylvie, Arzneimittel-Forschung/Drug Research, 1997, vol. 47, # 5, p. 635 - 642
  作者：Robert, Jean-Michel、Rideau, Odile、Robert-Piessard, Sylvie、Duflos, Muriel、Le Baut, Guillaume、Grimaud, Nicole、Juge, Marcel、Petit, Jean-Yves

  DOI：——

  日期：——