N-(4-azapentyl)acrylamide | 111774-36-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(4-azapentyl)acrylamide
• 英文别名: N-(4-azapentyl)-acrylamide；N-[3-(methylamino)propyl]prop-2-enamide
• CAS: 111774-36-8
• 化学式: C₇H₁₄N₂O
• 分子量: 142.201
• InChiKey: FYBCLPJRKYVSJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙烯酸乙酯 、 3-甲氨基丙胺 在 Novozym 435 作用下， 以 异丙醚 为溶剂， 反应 24.0h， 以53%的产率得到N-(4-azapentyl)acrylamide
  参考文献：
  名称：

  Lipase-catalyzed synthesis and characterization of a novel linear polyamidoamine oligomer

  摘要：

  A linear polyamidoamine oligomer was obtained by polymerization of ethyl acrylate and N-methyl-1,3-diaminopropane, catalyzed by the Candida antarctica lipase. Depending on the reaction conditions such as substrates concentration, solvent and enzyme:substrate ratio, the enzyme catalyzes the polymerization reaction or Michael adducts formation. The polymeric material, characterized by FTIR, H-1 and C-13 NMR and UV-MALDI-TOF-MS, shows low molecular weight and high monodispersity. The activity showed by C. antarctica lipase in the polymerization reaction is highly selective and allows to obtain a product with potential biomedical applications in mild condition reactions and low environmental impact. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2010.04.071

文献信息

• [EN] A NOVEL RNAi MOLECULE DELIVERY PLATFORM BASED ON SINGLE-siRNA AND shRNA NANOCAPSULES<br/>[FR] PLATEFORME D'ADMINISTRATION DE NOUVELLES MOLÉCULES D'ARNI BASÉES SUR DES NANOCAPSULES DE SIARN UNIQUE ET/OU SHARN
  申请人：UNIV CALIFORNIA

  公开号：WO2013138783A1

  公开（公告）日：2013-09-19

  Novel siRNA and shRNA nanocapsules and delivery methods are disclosed herein. These siRNA and shRNA nanocapsules and delivery methods are highly robust and effective. This invention provides a platform for RNAi delivery with low toxicity and long intracellular half-life for practical therapeutic applications.

  本文披露了新型siRNA和shRNA纳米胶囊及传递方法。这些siRNA和shRNA纳米胶囊及传递方法具有很高的稳健性和有效性。该发明为RNAi传递提供了一个平台，具有低毒性和长细胞内半衰期，可用于实际治疗应用。
• Aqueous ink composition, and ink jet recording method and recorded matter using the same
  申请人：Ota Hitoshi

  公开号：US20060173096A1

  公开（公告）日：2006-08-03

  The present invention provides n aqueous ink composition comprising a coloring component, an acetylene glycol-based surfactant, water, and a urea derivative, wherein the coloring component is a dispersion substance in which a colorant is enclosed with a dispersing polymer thereby being rendered dispersible in water, wherein the dispersing polymer comprises a hydrophobic part and a hydrophilic part, wherein at least a part of the hydrophilic part is a neutralized group obtained by neutralizing an unneutralized group constituting a part of the hydrophilic part, and wherein the neutralized groups are present within an amount range of from 20% to less than 60% in terms of molar ratio based on the sum of the neutralized groups and the unneutralized groups.

  本发明提供了一种包括着色组分、基于乙炔二醇的表面活性剂、水和脲衍生物的水性油墨组合物，其中着色组分是一种分散物质，其中颜料与分散聚合物一起封闭，从而使其能够在水中分散，其中分散聚合物包括疏水部分和亲水部分，其中至少部分亲水部分是通过中和构成亲水部分的未中和基团而获得的中和基团，其中中和基团在摩尔比例上基于中和基团和未中和基团的总和而在20%到小于60%的范围内存在。
• Vector
  申请人：Nakayama Yasuhide

  公开号：US20060057714A1

  公开（公告）日：2006-03-16

  The present invention provides a vector which can make nucleic acids to be an aggregate and locate a vector containing a cationic polymer to surround the aggregate so as to protect the nucleic acids from the enzyme. The vector comprises a polymer having branched chain(s). Preferably, 3, 4, or 6 branched chains are bonded to benzene ring. It is preferable that the number of the branched chains is higher. As the branched chain(s), a vinyl-series acrylic polymer is preferable. The vector is synthesized by reacting a dithiocarbamate compound with an acrylamide monomer for the branched chain(s).

  本发明提供了一种向量，该向量可以使核酸成为聚集体，并定位包含阳离子聚合物的向量以包围聚集体，从而保护核酸免受酶的影响。该向量包括具有支链的聚合物。最好将3、4或6个支链连接到苯环上。最好支链数量更多。作为支链，乙烯系丙烯酸聚合物是首选的。通过将二硫代氨基甲酸盐化合物与丙烯酰胺单体反应合成该向量。
• Cationic acrylamide and rubber modified asphalts
  申请人：OWENS-CORNING FIBERGLAS CORPORATION

  公开号：EP0082056A1

  公开（公告）日：1983-06-22

  Cationic chemically modified asphalts having utility for road construction, repair and maintenance as well as coating for various substrates, including cementitious substrates, glass and metal are provided. These asphalts are the product produced by reacting an acrylamide, asphalt, a vinyl aromatic monomer and a rubbery polymer.

  阳离子化学改性沥青可用于道路建设、维修和养护以及各种基材（包括水泥基材、玻璃和金属）的涂层。 这些沥青是丙烯酰胺、沥青、乙烯基芳香族单体和橡胶聚合物反应生成的产物。
• Composition of a dyeable poly-alpha-olefin and a copolymer
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0269293A2

  公开（公告）日：1988-06-01

  A melt kneaded mixture is formed of, by wt, (A) 100 parts of a poly-α-olefin (e.g. polypropylene); (B) 1 to 20 parts of an ethylene copolymer having a melt index as defined in JIS-6760 at 190°C of 1 to 1,000 g/10 mins, produced by high pressure continuous poly­merization with a free radical catalyst of (a) 40 to 95% of ethylene and (b) 5 to 60% of at least one dialkylaminoalkyl acrylamide comonomer represented by the formula: wherein R₁ is H or -CH₃; R₂ and R₃ each is hydrogen or C1-4 alkyl; and n is 2 to 4;       and optionally up to 20 wt% of an unsaturated ester (C) 0 to 3 parts of at least one alkali metal salt of a C7-24 organic carboxylic acid (e.g. a stearate); and optionally other additives. This composition can be melt spun into fibers or fabricated into other products, all of which are easily dyed especially with anionic dyes, alone or with other fibers.

  熔融捏合混合物由以下物质组成（按重量计）： 1、 (A) 100 份聚α-烯烃（如聚丙烯）； (B) 1 至 20 份乙烯共聚物，其熔融指数如 JIS-6760 中所定义，190°C 时为 1 至 1,000 克/10 分钟，该共聚物是在下列自由基催化剂的作用下，通过高压连续聚合反应制得的 (a) 40% 至 95% 的乙烯和 (b) 5%至 60%的至少一种二烷基氨基烷基丙烯酰胺共聚单体，其分子式为 其中 R₁ 是 H 或 -CH₃；R₂ 和 R₃ 各自是氢或 C1-4 烷基；n 是 2 至 4； 以及任选高达 20 wt%的不饱和酯 (C) 0 至 3 份至少一种 C7-24 有机羧酸的碱金属盐(如硬脂酸盐)；以及可选的其 他添加剂。 这种组合物可以熔融纺成纤维或制成其他产品，所有这些产品都很容易染色，尤其是单独或与其他纤维一起使用阴离子染料染色。