2-methylbut-3-en-2-yl N-[2-hydroxy-3-(2-methylbut-3-en-2-yloxycarbonylamino)propyl]carbamate | 945908-45-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methylbut-3-en-2-yl N-[2-hydroxy-3-(2-methylbut-3-en-2-yloxycarbonylamino)propyl]carbamate
• CAS: 945908-45-2
• 化学式: C₁₅H₂₆N₂O₅
• 分子量: 314.382
• InChiKey: MPANWJNKPYZTAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  96.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-methylbut-3-en-2-yl N-[2-hydroxy-3-(2-methylbut-3-en-2-yloxycarbonylamino)propyl]carbamate 在 吡啶 、 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 1,3-bis(2-methylbut-3-en-2-yloxycarbonylamino)propan-2-yl N-[3-[1,3-bis(2-methylbut-3-en-2-yloxycarbonylamino)propan-2-yloxycarbonylamino]-2-hydroxypropyl]carbamate
  参考文献：
  名称：

  Efficient synthesis of immolative carbamate dendrimer with olefinic periphery

  摘要：

  An efficient synthetic strategy for immolative carbarnate dendrons and dendrimers is described that requires no protection/deprotection in the convergent growth step. 1,3-Diamino-2-propanol was used as AB(2) building block and 4-nitrophenyl chloroformate as carbamate forming reagent. The method was demonstrated with a G3-dendron. A combination of convergent and divergent growth method was used to couple G2-dendrons to a G2-core or G3-dendrons to a tetrahedral G1-core with amine functional groups to form a spherical carbarnate dendrimer (G4) possessing an olefinic periphery. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.05.034
• 作为产物：
  描述：

  2-甲基-3-丁烯-2-醇 在 吡啶 、 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-methylbut-3-en-2-yl N-[2-hydroxy-3-(2-methylbut-3-en-2-yloxycarbonylamino)propyl]carbamate
  参考文献：
  名称：

  Efficient synthesis of immolative carbamate dendrimer with olefinic periphery

  摘要：

  An efficient synthetic strategy for immolative carbarnate dendrons and dendrimers is described that requires no protection/deprotection in the convergent growth step. 1,3-Diamino-2-propanol was used as AB(2) building block and 4-nitrophenyl chloroformate as carbamate forming reagent. The method was demonstrated with a G3-dendron. A combination of convergent and divergent growth method was used to couple G2-dendrons to a G2-core or G3-dendrons to a tetrahedral G1-core with amine functional groups to form a spherical carbarnate dendrimer (G4) possessing an olefinic periphery. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.05.034

文献信息

• Efficient synthesis of immolative carbamate dendrimer with olefinic periphery
  作者：Jeong-Kyu Lee、Young-Woong Suh、Mayfair C. Kung、Christopher M. Downing、Harold H. Kung

  DOI：10.1016/j.tetlet.2007.05.034

  日期：2007.7

  An efficient synthetic strategy for immolative carbarnate dendrons and dendrimers is described that requires no protection/deprotection in the convergent growth step. 1,3-Diamino-2-propanol was used as AB(2) building block and 4-nitrophenyl chloroformate as carbamate forming reagent. The method was demonstrated with a G3-dendron. A combination of convergent and divergent growth method was used to couple G2-dendrons to a G2-core or G3-dendrons to a tetrahedral G1-core with amine functional groups to form a spherical carbarnate dendrimer (G4) possessing an olefinic periphery. (c) 2007 Elsevier Ltd. All rights reserved.