N-(4-氟苯甲酰)哌啶 | 58547-67-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-氟苯甲酰)哌啶
• 英文名称: N-(p-fluorobenzoyl)piperidine
• 英文别名: (4-fluorophenyl)(piperidin-1-yl)methanone；(4-fluorophenyl)-piperidin-1-ylmethanone
• CAS: 58547-67-4
• 化学式: C₁₂H₁₄FNO
• mdl: MFCD00174322
• 分子量: 207.248
• InChiKey: UVBXLMBIXAPNBB-UHFFFAOYSA-N

物化性质

• 熔点：
  60 °C
• 沸点：
  332.5±25.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)
• 稳定性/保质期：

  在常温常压下保持稳定，应避免与水接触。

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933399090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 1-Fluoro-4-(piperidinocarbonyl)benzene
Synonyms: (4-Fluorophenyl)(piperidin-1-yl)methanone; (4-Fluorophenyl)carbonylpiperidine

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 1-Fluoro-4-(piperidinocarbonyl)benzene
CAS number: 58547-67-4

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C12H14FNO
Molecular weight: 207.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N-(4-氟苯甲酰)哌啶 在 三乙氧基硅烷 、 zinc diacetate 作用下， 以 四氢呋喃 为溶剂， 以92%的产率得到1-[(4-氟苯基)甲基]哌啶
  参考文献：
  名称：

  酰胺的锌催化还原：前所未有的选择性和官能团耐受性

  摘要：

  开发了一种新型的锌催化还原叔酰胺。该系统显示出显着的化学选择性和底物范围，可耐受酯、醚、硝基、氰基、偶氮和酮基取代基。

  DOI：

  10.1021/ja910083q
• 作为产物：
  描述：

  1-[(4-氟苯基)甲基]哌啶 在 1,5-二氮杂双环[4.3.0]壬-5-烯 、 氧气 、 rose bengal 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以74%的产率得到N-(4-氟苯甲酰)哌啶
  参考文献：
  名称：

  可见光介导的高效无金属催化剂，用于叔胺的α-加氧反应生成酰胺

  摘要：

  已经发现了一种无金属的体系，可以使用氧气作为氧化剂将叔胺有效地α-氧化为相应的酰胺。该可见光介导的氧化反应在温和的反应条件下表现出优异的底物范围，并且产生的水是唯一的副产物。通过应用于药物分子已证明了该方法的合成效用。最后，详细的机械反应清楚地表明了氧气和光催化剂的作用。

  DOI：

  10.1021/acscatal.8b01897

文献信息

• [EN] 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES AND THEIR USE AS 11-BETAHSD1 INHIBITORS<br/>[FR] DERIVES DE PIPERIDINE 1,4 DISUBSTITUEE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE 11-BETAHSD1
  申请人：ASTRAZENECA AB

  公开号：WO2004033427A1

  公开（公告）日：2004-04-22

  The use of a compound of formula (I) in the manufacture of a medicament for use in the inhibition of 11βHSD1 is described.

  使用式(I)的化合物制造用于抑制11βHSD1的药物。
• Iron-Catalyzed Direct Synthesis of Amides from Methylarenes
  作者：Surya Srinivas Kotha、Sindhura Badigenchala、Govindasamy Sekar

  DOI：10.1002/adsc.201401086

  日期：2015.5.4

  first catalytic process has been developed for the direct synthesis of amides from readily available petroleum by‐products (methylarenes) and amines using an iron catalyst. In this new catalytic reaction, the methyl group of the methylarene is oxidized to the corresponding aldehyde through non‐directed CH oxidation followed by its oxidative amidation with N‐chloroamine, yielding the carboxylic amide

  已开发出一种高效，绿色且首创的催化方法，用于使用铁催化剂从易于获得的石油副产品（甲基芳烃）和胺直接合成酰胺。在这个新的催化反应中，methylarene的甲基是通过非定向下氧化成相应的醛 ħ氧化，接着用其氧化酰胺化Ñ -chloroamine，得到羧酸酰胺。用铁催化剂氧化，叔丁基过氧化氢（TBHP）作为唯一氧化剂，在温和的反应条件下合成酰胺以及利用甲基芳烃作为起始原料，使该方法具有新颖性和环境友好性。
• Aerobic Oxidative Amidation of Aromatic and Cinnamic Aldehydes with Secondary Amines by CuI/2-Pyridonate Catalytic System
  作者：Mingwen Zhu、Ken-ichi Fujita、Ryohei Yamaguchi

  DOI：10.1021/jo301553v

  日期：2012.10.19

  A simple and convenient CuI/2-pyridonate catalytic system for the oxidative amidation of aldehydes with secondary amines has been developed. With this system, a variety of useful arylamides have been synthesized in moderate to good yields in the presence of small amount of copper catalyst and the pyridonate ligand, generating only water as a coproduct. Synthesis of cinnamamides was also achieved by

  开发了一种简单方便的CuI / 2-吡啶酮催化体系，用于醛与仲胺的氧化酰胺化反应。使用该系统，在少量铜催化剂和吡啶酸酯配体的存在下，已以中等至良好的产率合成了多种有用的芳基酰胺，仅产生水作为副产物。肉桂酰胺与仲胺的反应还可以中等产率合成肉桂酰胺。空气已成功地用作该催化系统中的绿色氧化剂，从而实现了安全，原子效率高的酰胺合成系统。
• Manganese‐Catalyzed Hydroborations with Broad Scope
  作者：Pradip Ghosh、Axel Jacobi von Wangelin

  DOI：10.1002/anie.202103550

  日期：2021.7.12

  synthetic manipulation and chemical valorization. The applications of catalytic hydrofunctionalization benefit from the use of liquid reducing agents and operationally facile setups. Metal-catalyzed hydroborations provide a highly prolific platform for reductive valorizations of stable C=X electrophiles. Here, we report an especially facile, broad-scope reduction of various functions including carbonyls

  容易获得的氧化物质的还原转化是合成操作和化学价值化的核心。催化加氢官能化的应用受益于液体还原剂的使用和操作简便的设置。金属催化的硼氢化反应为稳定的 C=X 亲电试剂的还原增值提供了一个高产的平台。在这里，我们报告了在非常温和的条件下，使用廉价的预催化剂 Mn(hmds) 2可以特别轻松、广泛地还原各种功能，包括羰基化合物、羧酸盐、吡啶、碳二亚胺和碳酸盐。该反应可以成功地应用于解聚。
• Copper-Catalyzed Aerobic Oxidative Amidation of Benzyl Alcohols
  作者：Scott W. Krabbe、Vincent S. Chan、Thaddeus S. Franczyk、Shashank Shekhar、José G. Napolitano、Carmina A. Presto、Justin A. Simanis

  DOI：10.1021/acs.joc.6b01686

  日期：2016.11.18

  A Cu-catalyzed synthesis of amides from alcohols and secondary amines using the oxygen in air as the terminal oxidant has been developed. The methodology is operationally simple requiring no high pressure equipment or handling of pure oxygen. The commercially available, nonprecious metal catalyst, Cu(phen)Cl2, in conjunction with di-tert-butyl hydrazine dicarboxylate and an inorganic base provides

  利用空气中的氧气作为末端氧化剂，从醇和仲胺中Cu催化合成酰胺已得到发展。该方法操作简单，不需要高压设备或纯氧气的处理。可商购的非贵金属催化剂Cu（phen）Cl 2与二叔丁基肼二羧酸酯和无机碱一起以中等到极好的收率提供了多种苯甲酰胺。胺共轭酸的p K a和醇的电子学被证明会影响碱的选择，以实现最佳反应性。提出了一种与观察到的反应性趋势，KIE和Hammett研究相一致的机制。