N-(4-溴苯基)-2-甲氧基苯甲酰胺 | 304686-21-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-溴苯基)-2-甲氧基苯甲酰胺
• 英文名称: N-(4-bromophenyl)-2-methoxybenzamide
• CAS: 304686-21-3
• 化学式: C₁₄H₁₂BrNO₂
• mdl: MFCD00700884
• 分子量: 306.159
• InChiKey: JSCDVENNYSRBMK-UHFFFAOYSA-N

物化性质

• 保留指数：
  2477

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对溴碘苯 、 2-甲氧基苯甲酰胺 在 caesium carbonate 作用下， 反应 14.0h， 以58%的产率得到N-(4-溴苯基)-2-甲氧基苯甲酰胺
  参考文献：
  名称：

  Activated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides

  摘要：

  DOI：

  10.1016/j.tet.2020.131858

文献信息

• Optimization and Antifungal Activity of Amide Analogues
  作者：Hui Feng、Li Leng、Jia Liu、Yuanmou Tang、Pengcheng Tang、Chixiang Zhang、Xioarong Tang、Shirong Jiao

  DOI：10.14233/ajchem.2013.13895

  日期：——

  Using salicylic acid as a lead compound, a series of its analogues (compounds 1-16) were designed and synthesized. Their activity of anti-pathogenic fungi of plants has been evaluated in the laboratory. The results showed that these compounds had certain antifungal activity against Sclerotinia sclerotiorum and Bipolaris maydis (Nisikado et Miyake) Shoem. Among them, the inhibition of growth for 2-(3-fluorophenylcarbamoyl)phenyl acetate (1) and 2-(3-chlorophenylcarbamoyl)phenyl acetate (2) reached 91.1 %, 92.8 % and 90.1 %, 90.1 % at a concentration of 100 mg L-1, respectively.

  以水杨酸为先导化合物，设计并合成了一系列水杨酸类似物（化合物 1-16）。在实验室中对其抗植物病原真菌的活性进行了评估。结果表明，这些化合物对 Sclerotinia sclerotiorum 和 Bipolaris maydis (Nisikado et Miyake) Shoem 具有一定的抗真菌活性。其中，2-(3-氟苯基氨基甲酰基)苯基乙酸酯（1）和 2-(3-氯苯基氨基甲酰基)苯基乙酸酯（2）在 100 mg L-1 浓度下的生长抑制率分别达到 91.1 %、92.8 % 和 90.1 %、90.1 %。
• Treating Long QT Syndrome
  申请人：MILAN David J.

  公开号：US20130310351A1

  公开（公告）日：2013-11-21

  This document relates to compounds useful for treating cardiac arrhythmias, for example, long QT syndrome. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient.
• US9447027B2
  申请人：——

  公开号：US9447027B2

  公开（公告）日：2016-09-20
• [EN] TREATING LONG QT SYNDROME<br/>[FR] TRAITEMENT DU SYNDROME DU QT LONG
  申请人：GEN HOSPITAL CORP

  公开号：WO2012054718A2

  公开（公告）日：2012-04-26

  This document relates to compounds useful for treating cardiac arrhythmias, for example, long QT syndrome. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient.
• Activated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides
  作者：Rong Zhao、Wenwen Dong、Jiangge Teng、Zhiwei Wang、Yunzhong Wang、Jianguo Yang、Qiang Jia、Changhu Chu

  DOI：10.1016/j.tet.2020.131858

  日期：2021.1