N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-2-aminooxy-acetamide | 1310583-29-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-2-aminooxy-acetamide
• 英文别名: N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-2-aminooxyacetamide
• CAS: 1310583-29-9
• 化学式: C₈H₁₉N₃O₄
• 分子量: 221.257
• InChiKey: NVASRKBDKFQDEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  11,12-didehydrodibenzo[a,e]cycloocten-5(6H)-one 、 N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-2-aminooxy-acetamide 在 溶剂黄146 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 48.0h， 以63%的产率得到N-{2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-2-(6H-11,12-didehydro-dibenzo[a,e]cycloocten-5-ylidene- aminooxy)-acetamide
  参考文献：
  名称：

  应变促进的炔-叠氮环加成 (SPAAC) 揭示了糖缀合物生物合成的新特征

  摘要：

  SPAAC 淘汰：已开发出一系列用于菌株促进的叠氮化物-炔烃环加成反应 (SPAAC) 的新试剂。这些与代谢标记和传统凝集素染色结合使用，以检查细胞中糖蛋白糖基化的缺陷。发现高尔基体运输的保真度和糖核苷酸的数量是生物合成的寡糖类型的关键参数。

  DOI：

  10.1002/cbic.201100117

文献信息

• ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS
  申请人：UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：US20160159732A1

  公开（公告）日：2016-06-09

  1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.

  1,3-双极功能化合物（例如，叠氮基功能化合物）可以与某些炔烃在环化反应中发生反应，形成杂环化合物。还公开了有用的炔烃（例如，受应力、环状炔烃）和制备这种炔烃的方法。1,3-双极功能化合物与炔烃的反应可用于各种应用，包括将生物分子固定在基底上。
• Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds
  申请人：University Of Georgia Research Foundation, Inc.

  公开号：EP2907525A2

  公开（公告）日：2015-08-19

  1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization ofbiomolecules on a substrate.

  1,3-二极官能团化合物（如叠氮官能团化合物）可与某些炔烃发生环化反应，形成杂环化合物。此外，还公开了有用的炔烃（如受约束的环状炔烃）和制造这类炔烃的方法。1,3-二极功能化合物与炔烃的反应可用于多种用途，包括将生物分子固定在基质上。
• DIBENZOCYCLOOCTENE-COMPOUNDS FOR BIOORTHOGONAL REACTIONS
  申请人：University Of Georgia Research Foundation, Inc.

  公开号：EP2907525B1

  公开（公告）日：2018-05-16
• Method of purifying/concentrating sugar chain with sugar chain-trapping molecule and mehtod of analyzing sugar chain structure
  申请人：Nishimura Shinichiro

  公开号：US20060188996A1

  公开（公告）日：2006-08-24

  The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance in a sample, comprising the steps of: a) contacting a sugar chain-trapping carrier comprising a substance which can specifically interact with sugar chains with the sample in a fluid phase under conditions that the sugar chain-trapping carrier can react with the sugar chains or sugar chain-containing substance; b) isolating a composite of the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance from the fluid phase; and c) exposing the composite to the conditions that the interaction between the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance is at least partially eliminated.
• METHOD OF PURIFYING/CONCENTRATING SUGAR CHAINS WITH A SUGAR CHAIN-TRAPPING MOLECULE AND METHOD OF ANALYZING SUGAR CHAIN STRUCTURE
  申请人：Sumitomo Bakelite Co., Ltd.

  公开号：US20150175652A1

  公开（公告）日：2015-06-25

  The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance in a sample, comprising the steps of: a) contacting a sugar chain-trapping carrier comprising a substance which can specifically interact with sugar chains with the sample in a fluid phase under conditions that the sugar chain-trapping carrier can react with the sugar chains or sugar chain-containing substance; b) isolating a composite of the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance from the fluid phase; and c) exposing the composite to the conditions that the interaction between the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance is at least partially eliminated.