2-thiophen-3-ylmethyl-2H-pyrazol-3-ylamine | 956506-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-thiophen-3-ylmethyl-2H-pyrazol-3-ylamine
• 英文别名: 1-(3-thienylmethyl)-1H-pyrazol-5-amine；2-(thiophen-3-ylmethyl)pyrazol-3-amine
• CAS: 956506-27-7
• 化学式: C₈H₉N₃S
• mdl: MFCD06655671
• 分子量: 179.246
• InChiKey: NDWSUFOXJFBUHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  72.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN
  申请人：VERSEON CORPORATION

  公开号：US20170326125A1

  公开（公告）日：2017-11-16

  There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.

  提供了用于抑制凝血酶的多取代芳香化合物，其中化合物包括取代的吡唑基或取代的三唑基。此外还提供了药物组合物。此外还提供了治疗和预防疾病或紊乱的方法，该疾病或紊乱可通过抑制凝血酶进行治疗或预防。
• [EN] TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS TÉTRAZOLIQUES COMME ANTAGONISTES DES RÉCEPTEURS À L'OREXINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009150614A1

  公开（公告）日：2009-12-17

  The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

  该发明涉及式(I)的四唑化合物，其中X、Y、Z、R1、R2和R3如描述中所述；其药学上可接受的盐，以及将这些化合物用作药物，特别是促进睡眠药物的药物受体拮抗剂。
• TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Aissaoui Hamed

  公开号：US20110086889A1

  公开（公告）日：2011-04-14

  The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R 1 , R 2 and R 3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

  该发明涉及式（I）的四唑化合物，其中X、Y、Z、R1、R2和R3如描述中所述；其药学上可接受的盐，以及将这些化合物用作药物，特别是促进睡眠的药物。
• Multisubstituted aromatic compounds as inhibitors of thrombin
  申请人：VERSEON CORPORATION

  公开号：US10653674B2

  公开（公告）日：2020-05-19

  There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.

  除其他外，还提供了可用于抑制凝血酶的多取代芳香族化合物，这些化合物包括取代的吡唑基或取代的三唑基。此外，还提供了药物组合物。另外还提供了治疗和预防疾病或紊乱的方法，这种疾病或紊乱可通过抑制凝血酶来治疗或预防。
• US9533967B2
  申请人：——

  公开号：US9533967B2

  公开（公告）日：2017-01-03