10-Dibrommethylen-phenanthron-(9) | 22648-86-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 10-Dibrommethylen-phenanthron-(9)
• 英文别名: 10-(Dibromomethylidene)phenanthren-9(10h)-one；10-(dibromomethylidene)phenanthren-9-one
• CAS: 22648-86-8
• 化学式: C₁₅H₈Br₂O
• 分子量: 364.036
• InChiKey: LJKBEYZAVCAINB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  四溴化碳 、 9,10-phenanthraquinone 在 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以50 mg的产率得到1,1,2,2-Tetrabrom-1,2-dihydro-cyclobutaphenanthren
  参考文献：
  名称：

  Hacker, Nigel P.; McOmie, John F. W.; Meunier-Piret, Jacqueline, Journal of the Chemical Society. Perkin transactions I, 1982, p. 19 - 24

  摘要：

  DOI：

文献信息

• HACKER, N. P.;MCOMIE, J. F. W.;MEUNIER-PIRET, J.;VAN, MEERSSCHE, M., J. CHEM. SOC. PERKIN TRANS., 1982, N 1, 19-23
  作者：HACKER, N. P.、MCOMIE, J. F. W.、MEUNIER-PIRET, J.、VAN, MEERSSCHE, M.

  DOI：——

  日期：——
• CHEMICAL AGENTS FOR THE PREVENTION OF INHIBITION OR TUMOR METASTASIS
  申请人：Bresnick Anne R.

  公开号：US20130090355A1

  公开（公告）日：2013-04-11

  The present invention provides methods of preventing or inhibiting tumor metastasis in a subject by administering a therapeutically effective amount of (1) a compound from a group of enumerated compounds, or a pharmaceutically acceptable salt thereof; (2) an agent that covalently modifies at least one cysteine residue of S100A4 protein; or (3) an agent that inhibits the interaction between S100A4 and myosin-IIA.
• [EN] CHEMICAL AGENTS FOR THE PREVENTION OR INHIBITION OF TUMOR METASTASIS<br/>[FR] AGENTS CHIMIQUES POUR LA PRÉVENTION OU L'INHIBITION DE MÉTASTASES TUMORALES
  申请人：EINSTEIN COLL MED

  公开号：WO2011146101A1

  公开（公告）日：2011-11-24

  The present invention provides methods of preventing or inhibiting tumor metastasis in a subject by administering a therapeutically effective amount of (1) a compound from a group of enumerated compounds, or a pharmaceutically acceptable salt thereof; (2) an agent that covalently modifies at least one cysteine residue of S100A4 protein; or (3) an agent that inhibits the interaction between S100A4 and myosin-IIA.
• Hacker, Nigel P.; McOmie, John F. W.; Meunier-Piret, Jacqueline, Journal of the Chemical Society. Perkin transactions I, 1982, p. 19 - 24
  作者：Hacker, Nigel P.、McOmie, John F. W.、Meunier-Piret, Jacqueline、Meerssche, Maurice Van

  DOI：——

  日期：——