2-azulenyl p-toluenesulfonate | 625843-33-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-azulenyl p-toluenesulfonate
• 英文别名: Azulen-2-yl 4-methylbenzenesulfonate；azulen-2-yl 4-methylbenzenesulfonate
• CAS: 625843-33-6
• 化学式: C₁₇H₁₄O₃S
• 分子量: 298.362
• InChiKey: ZCFWZNIYBRWRCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  四氢吡咯 、 2-azulenyl p-toluenesulfonate 反应 1.0h， 以65%的产率得到N-(Azulen-2-yl)pyrrolidine
  参考文献：
  名称：

  Synthesis of 2-aminoazulene derivatives. Nucleophilic and palladium-catalyzed amination of 2-substituted azulene

  摘要：

  Amination of 2-substituted azulene was carefully examined using several types of amines, and the scope and limitation of substrates and reagents in these direct nucleophilic aminations were found. The synthesis of 2-aminoazulenes was successfully achieved by the reaction of 2-bromoazulene with several amines via palladium-catalyzed amination. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.08.048
• 作为产物：
  描述：

  2-azulenyl trifluoromethanesulfonate 在 吡啶 、 二乙胺 、 sodium t-butanolate 作用下， 以 二氯甲烷 为溶剂， 反应 4.08h， 生成 2-azulenyl p-toluenesulfonate
  参考文献：
  名称：

  Synthesis of 2-aminoazulene derivatives. Nucleophilic and palladium-catalyzed amination of 2-substituted azulene

  摘要：

  Amination of 2-substituted azulene was carefully examined using several types of amines, and the scope and limitation of substrates and reagents in these direct nucleophilic aminations were found. The synthesis of 2-aminoazulenes was successfully achieved by the reaction of 2-bromoazulene with several amines via palladium-catalyzed amination. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.08.048

文献信息

• Synthesis of 2-aminoazulene derivatives. Nucleophilic and palladium-catalyzed amination of 2-substituted azulene
  作者：Ryuji Yokoyama、Shunji Ito、Tetsuo Okujima、Takahiro Kubo、Masafumi Yasunami、Akio Tajiri、Noboru Morita

  DOI：10.1016/j.tet.2003.08.048

  日期：2003.10

  Amination of 2-substituted azulene was carefully examined using several types of amines, and the scope and limitation of substrates and reagents in these direct nucleophilic aminations were found. The synthesis of 2-aminoazulenes was successfully achieved by the reaction of 2-bromoazulene with several amines via palladium-catalyzed amination. (C) 2003 Elsevier Ltd. All rights reserved.