N,N-Bis-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester | 869531-60-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N-Bis-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 4-[bis[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]-4-oxobutanoate；(2,5-dioxopyrrolidin-1-yl) 4-[bis[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]-4-oxobutanoate
• CAS: 869531-60-2
• 化学式: C₁₆H₁₈F₆N₄O₇
• 分子量: 492.332
• InChiKey: NLSBBYQENLLTEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  N,N-Bis-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester 在 水 、 sodium carbonate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 40.0h， 生成
  参考文献：
  名称：

  Dendrimeric Molecular Transporters:  Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake

  摘要：

  [GRAPHICS]Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.

  DOI：

  10.1021/ol051496y
• 作为产物：
  描述：

  2,2,2-trifluoro-N-[2-({2-[(trifluoroacetyl)amino]ethyl}amino)ethyl]acetamide 在 N,N'-二异丙基碳二亚胺 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成 N,N-Bis-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester
  参考文献：
  名称：

  Dendrimeric Molecular Transporters:  Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake

  摘要：

  [GRAPHICS]Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.

  DOI：

  10.1021/ol051496y

文献信息

• Dendrimeric Molecular Transporters:  Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake
  作者：Paul A. Wender、Erik Kreider、Erin T. Pelkey、Jonathan Rothbard、Christopher L. VanDeusen

  DOI：10.1021/ol051496y

  日期：2005.10.1

  [GRAPHICS]Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.