F1438-0002 | 5296-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: F1438-0002
• 英文别名: 1-piperidino-3-m-tolyloxy-propan-2-ol；1-(3-Methylphenoxy)-3-piperidin-1-ylpropan-2-ol
• CAS: 5296-11-7
• 化学式: C₁₅H₂₃NO₂
• mdl: MFCD00536597
• 分子量: 249.353
• InChiKey: UNJVLELDYUHSIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 1,2-环氧基-3-(3-甲基苯氧基丙烷) 生成 F1438-0002
  参考文献：
  名称：

  Ing; Ormerod, Journal of Pharmacy and Pharmacology, 1952, vol. 4, p. 21,25

  摘要：

  DOI：

文献信息

• Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect
  申请人：Friedrich-Alexander-Universität Erlangen-Nürnberg

  公开号：US10828281B2

  公开（公告）日：2020-11-10

  The present invention is directed to compounds, tautomers, stereoisomers, and chemically modified compounds thereof, and their use in preventing and/or treating tumors of metastasis and/or cartilage defect, and to a pharmaceutical composition comprising such compound.

  本发明涉及其化合物、同系物、立体异构体和化学修饰化合物，及其在预防和/或治疗肿瘤转移和/或软骨缺损中的用途，以及包含此类化合物的药物组合物。
• Ing; Ormerod, Journal of Pharmacy and Pharmacology, 1952, vol. 4, p. 21,25
  作者：Ing、Ormerod

  DOI：——

  日期：——
• BEGOVATOV, YU. M.;XAFIZOV, X.;KIMSANOV, B. X.;ISHANOVA, X. X., DOKL. AN TADZHSSR, 1984, 27, N 7, 383-386
  作者：BEGOVATOV, YU. M.、XAFIZOV, X.、KIMSANOV, B. X.、ISHANOVA, X. X.

  DOI：——

  日期：——
• TARGETED DRUG RESCUE WITH NOVEL COMPOSITIONS, COMBINATIONS, AND METHODS THEREOF
  申请人：VEPACHEDU SREENIVASARAO

  公开号：US20200069674A1

  公开（公告）日：2020-03-05

  Compounds of Formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, metabolites thereof, derivatives thereof, prodrugs thereof, acid addition salts thereof, pharmaceutically acceptable salts thereof, or N-oxides thereof; or a combination thereof; processes and intermediates for preparation thereof, compositions thereof, and uses thereof; are provided. Pharmaceutical compositions comprising a compound of Formula I, or enantiomers thereof, metabolites thereof, derivatives thereof, prodrugs thereof, acid addition salts thereof, pharmaceutically acceptable salts thereof, or N-oxides thereof; or a combination thereof; wherein the compound is a double and/or triple agent or ligand for CYP2D6, 5-HT2A, and/or 5HT2C receptors, and/or acetylcholinesterase are provided.
• 1-Aryloxy-3-[N-heterocyclicamino]-2-propanols¹
  作者：C. B. Pollard、R. W. Ingwalson

  DOI：10.1021/ja01617a083

  日期：1955.6