The present invention is directed to substituted thiazol-2-ylamine derivatives and pharmaceutically acceptable salts thereof that inhibit 11βHSD1 and that may be useful in the treatment of diseases in which modulation or inhibition of 11βHSD1 is beneficial or where a reduction in intracellular glucorticoid levels is desirable. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation or inhibition of 11βHSD1 is beneficial or where a reduction in intracellular glucorticoid levels is desirable.
本发明涉及取代
噻唑-2-基胺衍
生物及其药学上可接受的盐,其抑制11βH
SD1并可能有助于治疗调节或抑制11βH
SD1有益或需要降低细胞内糖皮质激素
水平的疾病。本发明还涉及包含这些化合物的制药组合物以及在治疗调节或抑制11βH
SD1有益或需要降低细胞内糖皮质激素
水平的疾病、疾病或病况中使用这些化合物和组合物的用途。