1-Benzyloxymethoxy-2,3-diphenyl-indolizine-7-carbonitrile | 660414-46-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-Benzyloxymethoxy-2,3-diphenyl-indolizine-7-carbonitrile
• 英文别名: 2,3-Diphenyl-1-(phenylmethoxymethoxy)indolizine-7-carbonitrile
• CAS: 660414-46-0
• 化学式: C₂₉H₂₂N₂O₂
• 分子量: 430.506
• InChiKey: QYYHRLYKZPCMHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二苯基环丙烯酮 在 sodium hydride 作用下， 以 四氢呋喃 、 1,2-二氯乙烷 为溶剂， 反应 40.0h， 生成 1-Benzyloxymethoxy-2,3-diphenyl-indolizine-7-carbonitrile
  参考文献：
  名称：

  Indolizines as novel potent inhibitors of 15-Lipoxygenase

  摘要：

  15-Lipoxygenase (15-LO) has been implicated in oxidation of low-density lipoproteins (LDL) and this enzyme may be involved in the development of atherosclerosis. We have examined 1-substituted indolizines as possible inhibitors of 15-LO from soy beans and from rabbit reticulocytes. Most compounds studied were significantly more active as inhibitors of 15-LO from soy beans than quercetin. The indolizines were slightly less potent inhibitors of the mammalian enzyme, but we found good correlation between inhibitory activity against both 15-LO enzymes studied. Several of the compounds were only weak DPPH scavengers and they may therefore be regarded as so-called non antioxidant inhibitors of 15-LO. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.09.033

文献信息

• Indolizines as novel potent inhibitors of 15-Lipoxygenase
  作者：Lise-Lotte Gundersen、Karl E Malterud、Ayele H Negussie、Frode Rise、Solomon Teklu、Ole Benny Østby

  DOI：10.1016/j.bmc.2003.09.033

  日期：2003.12

  15-Lipoxygenase (15-LO) has been implicated in oxidation of low-density lipoproteins (LDL) and this enzyme may be involved in the development of atherosclerosis. We have examined 1-substituted indolizines as possible inhibitors of 15-LO from soy beans and from rabbit reticulocytes. Most compounds studied were significantly more active as inhibitors of 15-LO from soy beans than quercetin. The indolizines were slightly less potent inhibitors of the mammalian enzyme, but we found good correlation between inhibitory activity against both 15-LO enzymes studied. Several of the compounds were only weak DPPH scavengers and they may therefore be regarded as so-called non antioxidant inhibitors of 15-LO. (C) 2003 Elsevier Ltd. All rights reserved.