(E)-4,4,5,5-tetrafluoropent-2-enoic acid | 1370280-58-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-4,4,5,5-tetrafluoropent-2-enoic acid
• CAS: 1370280-58-2
• 化学式: C₅H₄F₄O₂
• 分子量: 172.079
• InChiKey: QRWVRNLQAOBIEA-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (E)-4,4,5,5-tetrafluoropent-2-enoic acid 在 草酰氯 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  [EN] HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR USE IN THE TREATMENT HELMINTH INFECTION
  [FR] COMPOSÉS HÉTÉROARYLES À UNITÉ DE PONTAGE CYCLIQUE UTILISÉS DANS LE TRAITEMENT D'INFECTIONS HELMINTHIQUES

  摘要：

  本发明涉及某些杂环烯基化合物，用作药物，更具体地用作治疗动物的药物。该药物可用于治疗蠕虫感染和由蠕虫感染引起的寄生虫病的治疗。本发明还涉及利用这些化合物制备药物和治疗方法，包括将这些化合物给予需要治疗的动物。本发明还涉及包含这些化合物的药物组合物和配套工具。

  公开号：

  WO2013144180A1
• 作为产物：
  描述：

  ethyl 4,4,5,5-tetrafluoro-3-oxopentanoate 在 sodium tetrahydroborate 、 四磷十氧化物 、 sodium hydroxide 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 2.0h， 生成 (E)-4,4,5,5-tetrafluoropent-2-enoic acid
  参考文献：
  名称：

  [EN] N-HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR THE TREATMENT OF PARASITIC DISEASES
  [FR] COMPOSÉS N-HÉTÉROARYLÉS AYANT UNE UNITÉ PONTANTE CYCLIQUE POUR LE TRAITEMENT DE MALADIES PARASITAIRES

  摘要：

  这项发明涉及某些N-杂环芳基化合物，通常用作药物，更具体地用作动物药物。该药物可以优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。该发明还涉及利用这些化合物制备药物和治疗方法，包括将这些化合物用于需要治疗的动物的给药。此外，该发明还涉及N-杂环芳基化合物的制备。此外，该发明还涉及包含这些化合物的药物组合物和试剂盒。

  公开号：

  WO2012041872A1

文献信息

• N-heteroaryl compounds
  申请人：Berger Michael

  公开号：US08877934B2

  公开（公告）日：2014-11-04

  This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to novel N-heteroaryl compounds and the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些N-杂环芳基化合物，通常用作药物，更具体地用作动物药物。该药物可以优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。本发明还涉及使用该化合物制备药物和治疗方法，包括将该化合物用于需要治疗的动物的给药。本发明还涉及新型N-杂环芳基化合物及其制备。此外，本发明还涉及包含该化合物的药物组合物和试剂盒。
• N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
  申请人：Berger Michael

  公开号：US08883791B2

  公开（公告）日：2014-11-11

  This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of the N-heteroaryl compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些N-杂环芳基化合物，通常作为药物使用，更具体地作为动物药物。该药物可优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。本发明还涉及使用这些化合物制备药物和治疗方法，包括向需要治疗的动物施用这些化合物。本发明还涉及制备N-杂环芳基化合物，此外还涉及包含这些化合物的制药组合物和套装。
• N-HETEROARYL COMPOUNDS
  申请人：Berger Michael

  公开号：US20130196993A1

  公开（公告）日：2013-08-01

  This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to novel N-heteroaryl compounds and the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些N-杂环芳基化合物，通常作为药物使用，更具体地作为动物药物。该药物可优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。本发明还涉及利用该化合物制备药物和治疗方法，包括向需要治疗的动物投药物。本发明还涉及新型N-杂环芳基化合物及其制备。此外，本发明还涉及包含该化合物的制药组合物和试剂盒。
• N-HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR THE TREATMENT OF PARASITIC DISEASES
  申请人：Berger Michael

  公开号：US20130203768A1

  公开（公告）日：2013-08-08

  This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of the N-heteroaryl compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些N-杂环芳基化合物，通常作为药物使用，更具体地作为动物药物。该药物可优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。本发明还涉及使用该化合物制备药物和治疗方法，包括将该化合物用于需要治疗的动物的管理。本发明还涉及N-杂环芳基化合物的制备。此外，本发明还涉及包含该化合物的制药组合物和套装。
• HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT
  申请人：Intervet Inc.

  公开号：US20150080365A1

  公开（公告）日：2015-03-19

  This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth infections and the treatment of parasitosis caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及某些杂环芳基化合物，用作药物，更具体地用作治疗动物的药物。该药物可用于治疗蠕虫感染和由蠕虫感染引起的寄生虫病的治疗。本发明还涉及使用这些化合物制造药物和治疗，包括将这些化合物用于需要治疗的动物的给药。本发明还涉及包含这些化合物的制药组合物和套装。