1-(p-bromophenyl)-2-methyl-1H-naphth[2,3-d]imidazole-4,9-dione | 93657-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(p-bromophenyl)-2-methyl-1H-naphth[2,3-d]imidazole-4,9-dione
• 英文别名: BNID；1-<4-Brom-phenyl>-2-methyl-naphtho<2.3-d>imidazol-4.9-dion；1-(4-bromo-phenyl)-2-methyl-1H-naphtho[2,3-d]imidazole-4,9-dione；1-(4-Bromophenyl)-2-methyl-1H-naphtho(2,3-d)imidazole-4,9-dione；3-(4-bromophenyl)-2-methylbenzo[f]benzimidazole-4,9-dione
• CAS: 93657-41-1
• 化学式: C₁₈H₁₁BrN₂O₂
• 分子量: 367.202
• InChiKey: APVKJXLEZCSCCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  52
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Selection systems for genetically modified cells
  申请人：——

  公开号：US20030166201A1

  公开（公告）日：2003-09-04

  Compositions and methods for use in generating and selecting genetically modified cells are provided. The compositions include selectable markers and selection systems based thereon. Also provided are methods for the introduction and expression of heterologous nucleic acids in host animals that use the compositions and methods for generating and selecting genetically modified cells.

  提供了用于产生和选择转基因细胞的组合物和方法。这些组合物包括可选择标记和基于其的选择系统。还提供了在宿主动物中引入和表达异源核酸的方法，这些方法使用了用于产生和选择转基因细胞的组合物和方法。
• DIHYDROOROTATE DEHYDROGENASE INHIBITORS FOR THE TREATMENT OF VIRAL-MEDIATED DISEASES
  申请人：Institute of Molecular and Cell Biology

  公开号：EP1237546A2

  公开（公告）日：2002-09-11
• NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：GENZYME CORPORATION

  公开号：US20160287549A1

  公开（公告）日：2016-10-06

  The invention relates to dihydroorate dehydrogenase (DHODH) inhibitors useful for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis.
• US6841561B1
  申请人：——

  公开号：US6841561B1

  公开（公告）日：2005-01-11
• [EN] COMPOUNDS FOR THE TREATMENT OF VIRAL-MEDIATED DISEASES<br/>[FR] COMPOSES SERVANT A TRAITER DES MALADIES D'ORIGINE VIRALE
  申请人：INST OF MOLECUL & CELL BIOLOGY

  公开号：WO2001024785A2

  公开（公告）日：2001-04-12

  Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinearcarboxylic acid sodium salt (Brequinar). A synergistic effect can be obtained if an interferon such as interferon α2, interferon α8 or interferon β, or an inhibitor of a second enzyme selected from inosine monophosphate dehydrogenase, guanosine monophosphate synthetase, cytidine triphosphate synthetase and S-adenosylhomocysteine hydrolase, is also administered.