1-(3-methoxy-4-hydroxyphenyl)-7-(4-oxoacetoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione | 1347750-39-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1-(3-methoxy-4-hydroxyphenyl)-7-(4-oxoacetoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
• 英文别名: 2-[4-[(1E,6E)-7-(4-Hydroxy-3-methoxyphenyl)-3,5-dioxo-1,6-heptadien-1-yl]-2-methoxyphenoxy]acetic acid；2-[4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl]-2-methoxyphenoxy]acetic acid
• CAS: 1347750-39-3
• 化学式: C₂₃H₂₂O₈
• 分子量: 426.423
• InChiKey: ZUZNBJYTSIDJHS-FCXRPNKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-(3-methoxy-4-hydroxyphenyl)-7-(4-oxoacetoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione 在 盐酸 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 27.0h， 生成
  参考文献：
  名称：

  Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury

  摘要：

  We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2016.06.079
• 作为产物：
  描述：

  (4-甲酰基-2-甲氧基)苯氧基乙酸乙酯 在 boron trioxide 、 sodium hydroxide 作用下， 以 乙酸乙酯 、 丙酮 为溶剂， 反应 1.5h， 生成 1-(3-methoxy-4-hydroxyphenyl)-7-(4-oxoacetoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
  参考文献：
  名称：

  Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury

  摘要：

  We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2016.06.079

文献信息

• Lys修饰的姜黄素衍生物、其合成及应用
  申请人：首都医科大学

  公开号：CN104610089B

  公开（公告）日：2017-02-01

  本发明公开了下式的伪肽，进一步公开了它们的制备方法和用途。本发明的伪肽具有优秀的溶血栓活性、抗血栓活性、抗炎活性、OH自由基清除活性以及纳米结构。
• US8956589B2
  申请人：——

  公开号：US8956589B2

  公开（公告）日：2015-02-17
• Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury
  作者：Wei Bi、Yue Bi、Xiang Gao、Xin Yan、Yanrong Zhang、Jackie Harris、Thomas D. Legalley、K. Michael Gibson、Lanrong Bi

  DOI：10.1016/j.bmcl.2016.06.079

  日期：2016.8

  We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function. Published by Elsevier Ltd.