6-formyl-1-oxo-1,2,3,4-tetrahydroisoquinoline | 879887-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 6-formyl-1-oxo-1,2,3,4-tetrahydroisoquinoline
• 英文别名: 1-Oxo-1,2,3,4-tetrahydroisoquinoline-6-carbaldehyde；1-oxo-3,4-dihydro-2H-isoquinoline-6-carbaldehyde
• CAS: 879887-26-0
• 化学式: C₁₀H₉NO₂
• 分子量: 175.187
• InChiKey: VLUQHFRTRZEYMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-formyl-1-oxo-1,2,3,4-tetrahydroisoquinoline 在 盐酸 、 copper(II) bis(trifluoromethanesulfonate) 、 copper(l) chloride 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 甲苯 为溶剂， 反应 21.0h， 生成
  参考文献：
  名称：

  一种咪唑并吡啶衍生物的P2X3受体选择性调节剂及其药物用途

  摘要：

  本发明涉及一种咪唑并吡啶衍生物的P2X3受体选择性调节剂，具体的，涉及如式I所示的化合物及其消旋体、立体异构体、互变异构体、同位素标记物、溶剂化物、多晶型物、酯、前药或其药学上可接受的盐，以及包含其的药物组合物，其制备方法，及其医药用途，所述式I结构如下：

  公开号：

  CN115043836B
• 作为产物：
  描述：

  6-溴-3,4-二氢-2H-异喹啉-1-酮 、 N,N-二甲基甲酰胺 在 叔丁基锂 、 溶剂黄146 作用下， 以 四氢呋喃 、 正庚烷 为溶剂， 反应 2.08h， 以33%的产率得到6-formyl-1-oxo-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  Sulfonamide bicyclic compounds

  摘要：

  这项发明涵盖了Formula I的化合物，包括药用可接受的盐和溶剂化合物，它们的药物组合物，以及它们在抑制β-淀粉样肽（β-AP）产生中的应用。

  公开号：

  US20060063799A1

文献信息

• Sulfonamide bicyclic compounds
  申请人：Gilligan J. Paul

  公开号：US20060063799A1

  公开（公告）日：2006-03-23

  The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their uses in inhibiting β-amyloid peptide (β-AP) production.

  这项发明涵盖了Formula I的化合物，包括药用可接受的盐和溶剂化合物，它们的药物组合物，以及它们在抑制β-淀粉样肽（β-AP）产生中的应用。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577B1

  公开（公告）日：2018-12-12
• ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：Ise Toshihiro

  公开号：US20120126690A1

  公开（公告）日：2012-05-24

  As an organic electroluminescence device that has an excellent emission characteristic, suppresses a change in chromaticity when driving at a high temperature and has excellent durability, the organic electroluminescence device includes on a substrate a pair of electrodes and a light emitting layer disposed between the electrodes, in which the light emitting layer contains a compound represented by the following Formula (1) and a specific metal complex is provided. (Cz) p -L-(A) q (1) (In Formula (1), Cz represents a substituted or unsubstituted arylcarbazolyl group or a substituted or unsubstituted carbazolylaryl group. L represents a single bond, a substituted or unsubstituted arylene group, a substituted or unsubstituted cycloalkylene group or a substituted or unsubstituted aromatic heterocyclic ring. A is a substituted or unsubstituted nitrogen-containing aromatic heterocyclic six-membered ring, and each of p and q independently represent an integer of 1 to 6.)
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.