[3-(3-Bromophenyl)-1-phenylpyrazol-4-yl]methyl carbamimidothioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [3-(3-Bromophenyl)-1-phenylpyrazol-4-yl]methyl carbamimidothioate
• 化学式: C₁₇H₁₅BrN₄S
• 分子量: 387.3
• InChiKey: JAMOQXWEHMGOLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  93
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Compositions for Identifying Novel Compositions for the Treatment of Disease and Methods of Using Same
  申请人：SANCHEZ YOLANDA

  公开号：US20100209931A1

  公开（公告）日：2010-08-19

  Disclosed herein are compositions useful for identification of potential therapeutic agents for the treatment of a disorder associated with RAS deregulation or dysregulation. The compositions may be a yeast cell having one or more mutations in an IRA gene or an ERG gene. Also disclosed are methods of using these compositions.
• Methods and Compositions for the Treatment of RAS Associated Disorders
  申请人：Ratner Nancy

  公开号：US20120302581A1

  公开（公告）日：2012-11-29

  The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NF1 gene such as neurofibromatosis type I, fungal infections such as those caused by Candida albicans , and proliferative disorders such as glioblastoma.
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF RAS ASSOCIATED DISORDERS<br/>[FR] MÉTHODES ET COMPOSITIONS DESTINÉES AU TRAITEMENT DE TROUBLES ASSOCIÉS AU RAS
  申请人：CHILDRENS HOSP MEDICAL CENTER

  公开号：WO2010094009A2

  公开（公告）日：2010-08-19

  The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NFl gene such as neurofibromatosis type I and/or fungal infections such as those caused by Candida albicans.