Triphenyl bismuth diacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Triphenyl bismuth diacetate
• 英文别名: acetic acid;triphenylbismuthane
• 化学式: C22H23BiO4
• 分子量: 560.4
• InChiKey: XCPPRHDECCMBLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.38
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Triphenyl bismuth diacetate 、 2-哌啶甲酸乙酯 在 copper(II) acetate 二氯甲烷 、 水 、 magnesium sulfate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 18.0h， 以afforded a colorless oil (850 mg, crude)的产率得到1-phenyl-piperidine-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Anilino liver X-receptor modulators

  摘要：

  本发明涉及选择性LXR调节剂，对应于公式I的小分子化合物，同时还涉及使用公式I化合物的治疗有效剂量来治疗LXR调节的哺乳动物疾病的方法。

  公开号：

  US20040087632A1
• 作为试剂：
  描述：

  2,3-二氧代-2,3-二氢-1H-吲哚-5-甲腈 、 Triphenyl bismuth diacetate 在 铜 Triphenyl bismuth diacetate 、 氮气 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 Phenyl 5 cyanoisatin
  参考文献：
  名称：

  N-arylation of isatins

  摘要：

  本发明揭示了一种使用有机铋试剂进行异色酮的N-芳基化的方法。

  公开号：

  US05151518A1

文献信息

• Fluoromacrolides having immunosuppressive activity
  申请人：Merck & Co. Inc.

  公开号：US05189042A1

  公开（公告）日：1993-02-23

  Fluoromacrolides and derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by oxidation and fluorination at C-20. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma. Furthermore, these macrolides are useful as hair revitalizing agents, especially in the treatment of male pattern alopecia or alopecia senilis.

  通式I的氟代大环内酯及其衍生物已通过在C-20处的氧化和氟化反应从适当的前体制备而成。这些大环内酯免疫抑制剂在哺乳动物宿主中用于治疗自身免疫性疾病、感染性疾病和/或预防异种器官移植的排斥反应。此外，这些大环内酯免疫抑制剂在治疗炎症和过度增生的皮肤疾病以及免疫介导疾病的皮肤表现方面也很有用。此外，这些大环内酯在可逆性阻塞性呼吸道疾病，特别是哮喘的治疗中也很有用。此外，这些大环内酯还可用作头发复苏剂，特别是在男性型脱发或老年脱发的治疗中。
• Jnk inhibitor
  申请人：Itoh Fumio

  公开号：US20050148624A1

  公开（公告）日：2005-07-07

  A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O—, —N═, —NR 3 — or —CHR 3 —, R 2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R 1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.

  含有异喹啉酮骨架或其盐的JNK抑制剂，例如由以下式表示的化合物：其中环A和环B均为可选取代的苯环，X为—O—，—N═，—NR3—或—CHR3—，R2为酰基，可选的酯化或硫酯化羧基，可选的取代的氨基甲酰基或可选的取代的氨基基团等，破折号表示单键或双键，而R1为氢原子，可选的取代的碳氢基团，可选的取代的杂环基团等。
• Bicyclic compound, production and use thereof
  申请人：——

  公开号：US20040259876A1

  公开（公告）日：2004-12-23

  The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: 1 wherein, R 1 is a 5- to 6-membered ring group which may be substituted; X 1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X 2 is a bivalent group of 1 to 4 atoms; Z 1 is a bivalent cyclic ring group or the like; Z 2 is a bond or the like; and R 2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

  本发明提供了一种具有CCR拮抗剂活性，特别是CCR5拮抗剂活性的新型环状化合物以及其用途。本发明的化合物由下式表示：1其中，R1是一个可被取代的5-至6-成员环基团；X1是一个键或类似物；环A是一个可被取代的5-至6-成员环基团；环B是一个可被取代的8-至10-成员环基团；X2是1至4个原子的双价基团；Z1是一个双价环状基团或类似物；Z2是一个键或类似物；R2是氨基、含氮杂环基团（可被取代）或类似物的盐。
• O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having
  申请人：Merck & Co., Inc.

  公开号：US05250678A1

  公开（公告）日：1993-10-05

  O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma; as hair revitalizing agents, especially in the treatment of male pattern alopecia or alopecia senilis; in the reversal of multidrug resistance of tumor cells; in treatment of inflammation of mucosa and blood vessels, gastric ulcers, vascular damage, ischemic bowel disease, necrotizing enterocolitis, intestinal lesions associated with thermal burns; in the treatment of cytomegalovirus infection; and in the treatment of idiopathic thrombocytopenic purpura and Basedow's disease.

  通式I的O-芳基、O-烷基、O-烯基和O-炔基大环内酯，通过在环己烷环的C-3"和/或C-4"处烷基化和/或芳基化制备而成。这些大环内酯免疫抑制剂在哺乳动物宿主中用于治疗自身免疫性疾病、传染病和/或外源性器官移植排斥的预防。此外，这些大环内酯免疫抑制剂在治疗炎症和过度增生性皮肤疾病以及免疫介导疾病的皮肤表现方面具有应用价值。此外，这些大环内酯在可逆性阻塞性呼吸道疾病，尤其是哮喘的治疗中具有应用价值；作为头发复苏剂，特别是在男性型脱发或老年性脱发的治疗中；在肿瘤细胞多药耐药性的逆转中；在黏膜和血管炎症、胃溃疡、血管损伤、缺血性肠病、坏死性肠炎、与热烧伤相关的肠道损伤的治疗中；在巨细胞病毒感染的治疗中；以及在特发性血小板减少性紫癜和Basedow病的治疗中具有应用价值。
• O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having
  申请人：Merck & Co., Inc.

  公开号：US05693648A1

  公开（公告）日：1997-12-02

  Substituted compounds of the FK-506 Type. These compounds are useful for the same or essentially the same purposes as FK-506 and are applied in the same or a similar manner. These compounds are immunosuppressants and useful for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. Still other uses are described in the disclosure.

  FK-506类型的替代化合物。这些化合物可用于与FK-506相同或基本相同的目的，并以相同或类似的方式应用。这些化合物是免疫抑制剂，可用于治疗自身免疫性疾病、传染病和/或预防异种器官移植排斥。还描述了其他用途。