(3-chloro-phenyl)-[1-(4-chloro-phenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine | 5346-51-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (3-chloro-phenyl)-[1-(4-chloro-phenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine
• 英文别名: (3-Chlor-phenyl)-[1-(4-chlor-phenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amin；n-(3-Chlorophenyl)-1-(4-chlorophenyl)-6-methyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine；N-(3-chlorophenyl)-1-(4-chlorophenyl)-6-methylpyrazolo[3,4-d]pyrimidin-4-amine
• CAS: 5346-51-0
• 化学式: C₁₈H₁₃Cl₂N₅
• 分子量: 370.241
• InChiKey: BZXRZOMGMLZNQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION
  申请人：Aktas Bertal Huseyin

  公开号：US20120115915A1

  公开（公告）日：2012-05-10

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

  本文提供了抑制翻译起始的组合物和方法。描述了使用N，N'-二芳基脲和/或N，N'-二芳基硫脲化合物治疗（1）细胞增生性疾病，（2）非增生性退行性疾病，（3）病毒感染和/或（4）与病毒感染相关的疾病的组合物、方法和试剂盒。
• N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation
  申请人：President and Fellows of Harvard College

  公开号：US20160318857A1

  公开（公告）日：2016-11-03

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.
• US9421211B2
  申请人：——

  公开号：US9421211B2

  公开（公告）日：2016-08-23
• US9932300B2
  申请人：——

  公开号：US9932300B2

  公开（公告）日：2018-04-03