4-ethyl-2,3-dihydro-1H-inden-5-ol | 125443-09-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4-ethyl-2,3-dihydro-1H-inden-5-ol
• CAS: 125443-09-6
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: SMIISEZZSMFAIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-ethyl-2,3-dihydro-1H-inden-5-ol 在 palladium on activated charcoal 氢气 作用下， 生成 3-ethyl-4-methyl-5-(2-formyl-3-methyl-4,5,6,7-tetrahydro-7-indolyl)-pyrrole-2-carboxylic acid
  参考文献：
  名称：

  关于六元碳环在卟啉环化中的修饰影响：内消旋，β-丙卟啉的合成

  摘要：

  具有六元环外环的卟啉是通过MacDonald缩合和a，c-biladiene路线合成的。

  DOI：

  10.1016/s0040-4039(00)88464-6
• 作为产物：
  描述：

  5-acetoxy-4-ethyl-2,3-dihydro-1H-indene 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以92%的产率得到4-ethyl-2,3-dihydro-1H-inden-5-ol
  参考文献：
  名称：

  Enynones in Organic Synthesis. 8. Synthesis of the Antimicrobial-Cytotoxic Agent Juncusol and Members of the Effusol Class of Phenols

  摘要：

  Two new syntheses of phenols have been developed which have been utilized in an efficient preparation of the antimicrobial-cytotoxic agent juncusol (22) and several members of the effusol (23) class of phenols. These results complement our earlier studies with enynones of type 42 and provide for the highly efficient conversion of 42 to either methylenecyclopentenones 45 or phenols of type 47 or 54 with virtually 100% selectivity.

  DOI：

  10.1021/jo00107a017

文献信息

• JACOBI, PETER A.;KRAVITZ, JOSEPH I., TETRAHEDRON LETT., 29,(1988) N 52, C. 6873-6876
  作者：JACOBI, PETER A.、KRAVITZ, JOSEPH I.

  DOI：——

  日期：——
• Enynones in Organic Synthesis. 8. Synthesis of the Antimicrobial-Cytotoxic Agent Juncusol and Members of the Effusol Class of Phenols
  作者：Peter A. Jacobi、Joseph I. Kravitz、Wanjun Zheng

  DOI：10.1021/jo00107a017

  日期：1995.1

  Two new syntheses of phenols have been developed which have been utilized in an efficient preparation of the antimicrobial-cytotoxic agent juncusol (22) and several members of the effusol (23) class of phenols. These results complement our earlier studies with enynones of type 42 and provide for the highly efficient conversion of 42 to either methylenecyclopentenones 45 or phenols of type 47 or 54 with virtually 100% selectivity.
• On the modifying influence of six-membered carbocyclic rings in porphyrin cyclizations: Synthesis of meso, β-propanoporphyrins
  作者：Timothy D Lash

  DOI：10.1016/s0040-4039(00)88464-6

  日期：1988.1

  Porphyrins with six-membered exocyclic rings have been synthesised by the MacDonald condensation and the a,c-biladiene route.

  具有六元环外环的卟啉是通过MacDonald缩合和a，c-biladiene路线合成的。