5-hydrazinyl-3-methylisothiazole | 1228092-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-hydrazinyl-3-methylisothiazole
• 英文别名: (3-Methyl-isothiazol-5-yl)-hydrazine；(3-methyl-1,2-thiazol-5-yl)hydrazine
• CAS: 1228092-11-2
• 化学式: C₄H₇N₃S
• mdl: MFCD19203182
• 分子量: 129.186
• InChiKey: WIPLJBKAXYGBSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  79.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 3-aceto-4-oxo-4-(4-chlorophenyl)butanoate 、 5-hydrazinyl-3-methylisothiazole 在 硫酸 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以14.9%的产率得到methyl [5-(4-chlorophenyl)-3-methyl-1-(3-methylisothiazol-5-yl)-1H-pyrazol-4-yl]acetate
  参考文献：
  名称：

  SUBSTITUTED 1-(THIAZOLYL)-AND 1-(ISOTHIAZOLYL)PYRAZOL-4-YLACETIC ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS

  摘要：

  这项发明涉及一般式(I)的1-(噻唑基)-和1-(异噻唑基)吡唑-4-基乙酸衍生物及其盐，其中Het，R1，R2，R3，R4，R5，R6和n如权利要求1所定义。化合物(I)或其盐适用于用作除草剂和植物生长调节剂，特别是作为对有用植物作物中有害植物的选择性控制除草剂，并且可以通过权利要求9中描述的方法制备。

  公开号：

  US20100197501A1

文献信息

• Substituted 1-(thiazolyl)-and 1-(isothiazolyl)pyrazol-4-ylacetic acids, processes for their preparation and their use as herbicides and plant growth regulators
  申请人：Bayer CropScience AG

  公开号：US08067611B2

  公开（公告）日：2011-11-29

  The invention relates to 1-(thiazolyl)- and 1-(isothiazolyl)pyrazol-4-ylacetic acid derivatives of the general formula (I) and salts thereof in which Het, R1, R2, R3, R4, R5, R6 and n are as defined in claim 1. The compounds (I) or salts thereof are suitable for use as herbicides and plant growth regulators, in particular as herbicides for the selective control of harmful plants in crops of useful plants and can be prepared by processes as described in claim 9.

  本发明涉及一般式(I)及其盐的1-(噻唑基)-和1-(异噻唑基)吡唑-4-乙酸衍生物，其中Het、R1、R2、R3、R4、R5、R6和n如权利要求1中所定义。化合物(I)或其盐适用于作为除草剂和植物生长调节剂，特别适用于作为用于选择性控制有害植物在有用植物作物中的除草剂，并可通过权利要求9所述的方法制备。
• Pyridazinones
  申请人：Hoffmann-La Roche Inc.

  公开号：US08178538B2

  公开（公告）日：2012-05-15

  The present invention is concerned with novel pyridazinones of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of CNS disorders.

  本发明涉及式（I）的新型吡啶二酮，其中R1、R2、R3和R4在说明书和权利要求中定义，以及其生理上可接受的盐和酯。这些化合物抑制PDE10A，可用于治疗中枢神经系统疾病。
• PYRIDAZINONES
  申请人：Alberati Daniela

  公开号：US20100152193A1

  公开（公告）日：2010-06-17

  The present invention is concerned with novel pyridazinones of formula (I) wherein R 1 , R 2 , R 3 and R 4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of CNS disorders.

  本发明涉及式（I）的新型吡啶二酮化合物，其中R1、R2、R3和R4如所述和所述权利要求中定义，以及其生理上可接受的盐和酯。这些化合物抑制PDE10A，并可用于治疗中枢神经系统疾病。
• SUBSTITUTED 1-(THIAZOLYL)-AND 1-(ISOTHIAZOLYL)PYRAZOL-4-YLACETIC ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS
  申请人：Martelletti Arianna

  公开号：US20100197501A1

  公开（公告）日：2010-08-05

  The invention relates to 1-(thiazolyl)- and 1-(isothiazolyl)pyrazol-4-ylacetic acid derivatives of the general formula (I) and salts thereof in which Het, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined in claim 1. The compounds (I) or salts thereof are suitable for use as herbicides and plant growth regulators, in particular as herbicides for the selective control of harmful plants in crops of useful plants and can be prepared by processes as described in claim 9.

  这项发明涉及一般式(I)的1-(噻唑基)-和1-(异噻唑基)吡唑-4-基乙酸衍生物及其盐，其中Het，R1，R2，R3，R4，R5，R6和n如权利要求1所定义。化合物(I)或其盐适用于用作除草剂和植物生长调节剂，特别是作为对有用植物作物中有害植物的选择性控制除草剂，并且可以通过权利要求9中描述的方法制备。