N-[cyano(phenyl)methyl]methanesulfonamide | 1020855-53-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[cyano(phenyl)methyl]methanesulfonamide
• CAS: 1020855-53-1
• 化学式: C₉H₁₀N₂O₂S
• 分子量: 210.257
• InChiKey: AVYXKSAJXHYFQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三甲基氰硅烷 、 N-(苯基亚甲基)甲磺酰胺 在 NanoActive Plus magnesium oxide 作用下， 以 四氢呋喃 为溶剂， 反应 0.03h， 以96%的产率得到N-[cyano(phenyl)methyl]methanesulfonamide
  参考文献：
  名称：

  Synthesis of α-amino nitriles through Strecker reaction of aldimines and ketoimines by using nanocrystalline magnesium oxide

  摘要：

  Strecker reactions of various aldimines as well as ketoimines with TMSCN proceeded smoothly under mild conditions to give the corresponding alpha-amino nitriles and alpha,alpha-disubstituted alpha-amino nitriles, respectively, in good to excellent yields in the presence of nanocrystalline magnesium oxide. The reaction proceeds through hypervalent silicate species by coordination to O2-/O- (Lewis basic site) of nanocrystalline magnesium oxide, proved by Si-29 NMR. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.128

文献信息

• TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF
  申请人：Hisamichi Hiroyuki

  公开号：US20100227866A1

  公开（公告）日：2010-09-09

  [Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). [Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

  [问题] 提供一种药物，特别是一种可用作治疗肠易激综合征（IBS）的治疗剂。 [解决问题的方法] 发现一种在4位具有酰胺基团或其药学上可接受的盐的四氢异喹啉-1-酮衍生物具有优异的肽释放因子2（BB2）受体拮抗作用。还发现四氢异喹啉-1-酮衍生物对肠道运动障碍非常有效。由此可见，本发明的四氢异喹啉-1-酮衍生物对与BB2受体相关的疾病，特别是IBS，具有治疗剂的用途。
• Tetrahydroisoquinolin-1-one derivative or salt thereof
  申请人：Seldar Pharma Inc.

  公开号：US10016410B2

  公开（公告）日：2018-07-10

  To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

  提供一种药物，特别是一种可用作肠易激综合征（IBS）治疗剂的化合物。研究发现，一种在 4 位具有酰胺基团的四氢异喹啉-1-酮衍生物或其药学上可接受的盐具有很好的蚕豆素 2（BB2）受体拮抗作用。研究还发现，四氢异喹啉-1-酮衍生物对肠道运动障碍也有很好的疗效。综上所述，本发明的四氢异喹啉-1-酮衍生物可作为一种治疗剂，用于治疗与 BB2 受体相关的疾病，特别是肠易激综合征。
• US8486970B2
  申请人：——

  公开号：US8486970B2

  公开（公告）日：2013-07-16
• US9150541B2
  申请人：——

  公开号：US9150541B2

  公开（公告）日：2015-10-06
• US9526719B2
  申请人：——

  公开号：US9526719B2

  公开（公告）日：2016-12-27