2-[4-(2,3-epoxypropoxy)-phenyl]-4-(trifluoromethyl)-imidazole | 62911-13-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(2,3-epoxypropoxy)-phenyl]-4-(trifluoromethyl)-imidazole
• 英文别名: 2-(4-oxiranylmethoxy-phenyl)-4-trifluoromethyl-1(3)H-imidazole；2-[4-(oxiran-2-ylmethoxy)phenyl]-5-(trifluoromethyl)-1H-imidazole
• CAS: 62911-13-1
• 化学式: C₁₃H₁₁F₃N₂O₂
• 分子量: 284.238
• InChiKey: ODRIDSWZAYARNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[4-(2,3-epoxypropoxy)-phenyl]-4-(trifluoromethyl)-imidazole 在 异丙胺 、 硝基甲烷 、 乙腈 作用下， 以 异丙胺 为溶剂， 反应 23.0h， 以of 2-[4-(3-isopropylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole is obtained的产率得到2-[4-(3-isopropylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole
  参考文献：
  名称：

  3-Amino-2-OR-propoxyaryl substituted imidazoles

  摘要：

  本发明公开了一种3-氨基-2-OR-丙氧基芳基取代咪唑及其制备方法。这些咪唑及其盐具有药理活性，包括降压活性和β-肾上腺素能阻滞活性。

  公开号：

  US04134983A1
• 作为产物：
  描述：

  1-chloro-3-[4-(4-trifluoromethyl-1(3)H-imidazol-2-yl)-phenoxy]-propan-2-ol 在 氢氧化钾 作用下， 以 甲醇 、 正己烷 、 苯 为溶剂， 生成 2-[4-(2,3-epoxypropoxy)-phenyl]-4-(trifluoromethyl)-imidazole
  参考文献：
  名称：

  3-Amino-2-hydroxypropoxyaryl imidazole derivatives

  摘要：

  揭示了公式为##STR1##的新型取代咪唑类化合物以及它们的制备方法。这些咪唑类化合物及其盐表现出药理活性，包括抗高血压活性和β-肾上腺素受体阻滞活性。

  公开号：

  US04440774A1

文献信息

• Certain antihypertensive 1-[2-[3-carbamoyl-4-hydroxy phenoxy]alkylene
  申请人：Ciba-Geigy Corporation

  公开号：US04559354A1

  公开（公告）日：1985-12-17

  The invention relates to novel substituted phenyl ethers of the formula ##STR1## in which Ar represents a mono- or bi-cyclic carbocyclic aryl radical, or a mono- or bi-cyclic heterocyclic aryl radical bonded to a phenylene radical by way of a ring carbon atom, Ph represents a phenylene radical, n has the value 0 to 1 and alk represents alkylene having from 2 to 5 carbon atoms, the nitrogen atom and the oxygen atom or, if n is 0, the aromatic radical being separated from each other by at least two carbon atoms in the unbranched chain, and R.sub.1 and R.sub.2 each represents, independently of the other, hydrogen or lower alkyl, or together represent lower alkylene, oxa-lower alkylene, thia-lower alkylene, aza-lower alkylene or N-lower alkyl-aza-lower alkylene, and salts thereof, especially pharmaceutically acceptable non-toxic acid addition salts. Such compounds possess, on the one hand, blocking properties towards .beta.-adrenergic receptors and can therefore be used as .beta.-receptor-blockers with or without cardioselectivity for the treatment of Angina pectoris, hypertrophic cardiomyopathy and heart rhythm disorders and also as blood-pressure-reducing agents. On the other hand, such compounds possess .beta.-receptor-stimulating properties and can therefore be used as positively inotropically active agents, especially as cardiotonics, for the treatment of heart muscle insufficiency.

  该发明涉及新型取代苯醚化合物，其化学式为##STR1##其中Ar代表单环或双环碳环芳基，或通过环碳原子与苯基相连的单环或双环杂环芳基，Ph代表苯基，n取值为0至1，alk代表具有2至5个碳原子的烷基，氮原子和氧原子或者如果n为0，则芳基在直链中至少被至少两个碳原子分隔，R.sub.1和R.sub.2分别独立地代表氢或低烷基，或者一起代表低烷基，氧杂低烷基，硫杂低烷基，氮杂低烷基或N-低烷基-氮杂低烷基，以及其盐，特别是药学上可接受的无毒酸盐。这类化合物一方面具有对β-肾上腺素受体的阻滞作用，因此可用作具有或不具有心脏选择性的β-受体阻滞剂，用于治疗心绞痛、肥厚型心肌病和心律失常，也可用作降压药。另一方面，这类化合物具有β-受体激动作用，因此可用作具有正肌力作用的药剂，特别是作为心力衰竭的治疗药物。
• .beta.-adrenergic blocking imidazolylphenoxy propanolamines
  申请人：Merck & Co., Inc.

  公开号：US04642311A1

  公开（公告）日：1987-02-10

  Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity. ##STR1##

  公开了取代咪唑和其制备方法。这些咪唑及其盐表现出药理活性，包括降压活性和β-肾上腺素受体阻滞活性。
• .beta.-blocking substituted imidazoles
  申请人：Merck & Co., Inc.

  公开号：US04853383A1

  公开（公告）日：1989-08-01

  Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

  揭示了一种新型替代咪唑并其制备方法。这些咪唑及其盐具有药理活性，包括抗高血压活性和β-肾上腺素能阻断活性。
• 3-Amino-2-or-propoxy-tetrahydronaphthyl or indanyl-substituted
  申请人：Merck & Co., Inc.

  公开号：US04199580A1

  公开（公告）日：1980-04-22

  Novel 3-amino-2-OR-propoxy-tetrahydronaphthyl or indanyl substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

  本发明揭示了3-氨基-2-OR-丙氧基-四氢萘基或印安基取代咪唑的方法及其制备方法。这些咪唑及其盐表现出药理活性，包括降压活性和β-肾上腺素能阻滞活性。
• .beta.-Adrenergic 2-[4-(3-amino-2-hydroxypropoxy)phenyl]imidazoles
  申请人：Merck & Co., Inc.

  公开号：US04567276A1

  公开（公告）日：1986-01-28

  Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

  本发明揭示了一种代替咪唑的新型咪唑化合物及其制备方法。这些咪唑化合物及其盐具有药理活性，包括抗高血压活性和β-肾上腺素能阻滞活性。