2-phenyl-1-pyrrol-2-yl-ethanol | 857426-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-phenyl-1-pyrrol-2-yl-ethanol
• 英文别名: 2-Phenyl-1-pyrrol-2-yl-aethanol；2-phenyl-1-(1H-pyrrol-2-yl)ethanol
• CAS: 857426-52-9
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: HWAHUXVRLKWKFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  36
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-phenyl-1-pyrrol-2-yl-ethanol 在 氢氧化钾 作用下， 生成 (E)-2-styryl-1H-pyrrole
  参考文献：
  名称：

  2-Vinylpyrrole and Homologs

  摘要：

  DOI：

  10.1021/ja01631a073
• 作为产物：
  描述：

  2-phenyl-1-(1H-pyrrol-2-yl)ethanone 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 2-phenyl-1-pyrrol-2-yl-ethanol
  参考文献：
  名称：

  2-Vinylpyrrole and Homologs

  摘要：

  DOI：

  10.1021/ja01631a073

文献信息

• Practical Cu(OAc)2/TEMPO-catalyzed selective aerobic alcohol oxidation under ambient conditions in aqueous acetonitrile
  作者：Jian-An Jiang、Jia-Lei Du、Zhan-Guo Wang、Zhong-Nan Zhang、Xi Xu、Gan-Lin Zheng、Ya-Fei Ji

  DOI：10.1016/j.tetlet.2013.09.050

  日期：2014.3

  We reported a ligand- and additive-free Cu(OAc)(2)/TEMPO catalyst system that enables efficient and selective aerobic oxidation of a broad range of primary and secondary benzylic alcohols, primary and secondary 1-heteroaryl alcohols, cinnamyl alcohols, and aliphatic alcohols to the corresponding aldehydes and ketones. This ambient temperature oxidation protocol is of practical features like aqueous acetonitrile as solvent, ambient air as the terminal oxidant, and low catalyst loading, presenting a potential value in terms of both economical and environmental considerations. Based on the experimental observations, a plausible reaction mechanism was proposed. (C) 2013 Elsevier Ltd. All rights reserved.
• Efficient Synthesis of Bis(heterocyclyl)methanes
  作者：Kamaljit Singh、Shivali Sharma、Amit Sharma

  DOI：10.1080/00397911.2010.518330

  日期：2011.12.1

  The reaction of pyrrole/furan aldehyde with Grignard reagent and pyrrole/N-methyl pyrrole in sequence allows efficient synthesis of a number of meso-elaborated bis(heterocyclyl)methanes, which are otherwise difficult to obtain through a direct aldehyde condensation route.
• 2-Vinylpyrrole and Homologs
  作者：Werner Herz、Charles F. Courtney

  DOI：10.1021/ja01631a073

  日期：1954.1